Potential role of CCR5 polymorphism in the development of AIDS dementia complex

Abstract The chemokine receptor CCR5 and to a lesser extent CCR2b and CCR3 have been shown to serve as coreceptors for HIV-1 entry into macrophages. Individuals that are homozygous for a defective CCR5 allele (ΔCCR5) are highly, but not fully, resistant to infection with HIV-1. Here, we want to emph...

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Bibliographic Details
Published in:FEMS immunology and medical microbiology 1999-12, Vol.26 (3-4), p.243-247
Main Authors: Boven, Leonie A., van der Bruggen, Tjomme, van Asbeck, B. Sweder, Marx, Joannes J.M., Nottet, Hans S.L.M.
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
AIDS
AIDS dementia
AIDS Dementia Complex - etiology
AIDS Dementia Complex - genetics
AIDS Dementia Complex - virology
AIDS/HIV
Alleles
CCR5
CCR5 protein
Chemokines
Dementia
Dementia disorders
Gene polymorphism
Gene Products, tat - metabolism
Genotype
Heterozygote
HIV
HIV-1 - physiology
Human immunodeficiency virus
Humans
In vivo methods and tests
Macrophage
Macrophages
Macrophages - virology
Polymerase Chain Reaction
Polymorphism
Polymorphism, Genetic
Receptors, CCR5 - genetics
RNA, Viral - analysis
tat Gene Products, Human Immunodeficiency Virus
Virus Replication
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Summary:Abstract The chemokine receptor CCR5 and to a lesser extent CCR2b and CCR3 have been shown to serve as coreceptors for HIV-1 entry into macrophages. Individuals that are homozygous for a defective CCR5 allele (ΔCCR5) are highly, but not fully, resistant to infection with HIV-1. Here, we want to emphasize the importance of ΔCCR5 in in vitro as well as in vivo studies. We provide data that suggest that CCR5 polymorphism may affect the onset of AIDS dementia complex in vivo and data that show that HIV-1 replication is influenced by the ΔCCR5 allele in vitro. Knowing the CCR5 genotype of an individual will help to better interpret research results and may even provide new information about mechanisms of disease.
ISSN:0928-8244
1574-695X
2049-632X
DOI:10.1111/j.1574-695X.1999.tb01395.x