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Determination of bromide in canine plasma using ion chromatography
A new ion chromatographic procedure has been developed and validated for the determination of bromide in canine plasma. Following a simple dilution, samples were separated on a Metrosep A Supp 5 column. The mobile phase was an isocratic mixture of 2.2 mM Na 2CO 3, 1.0 mM NaHCO 3, and 1% acetonitrile...
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| Published in: | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2008-07, Vol.870 (2), p.255-258 |
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| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c394t-7c741f8c88f75f47743ba987973283e8668813c2405bbc8205e07a54e65a89ce3 |
| container_end_page | 258 |
| container_issue | 2 |
| container_start_page | 255 |
| container_title | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences |
| container_volume | 870 |
| creator | Cox, S.K. Whiton, A.M. Bowman, H.L. |
| description | A new ion chromatographic procedure has been developed and validated for the determination of bromide in canine plasma. Following a simple dilution, samples were separated on a Metrosep A Supp 5 column. The mobile phase was an isocratic mixture of 2.2
mM Na
2CO
3, 1.0
mM NaHCO
3, and 1% acetonitrile, with a flow-rate of 0.7
ml/min. The procedure produced a linear curve over the concentration range of 50–2500
μg/ml. The development of the assay permitted the determination of therapeutic levels after oral administration of potassium bromide to dogs being treated for epilepsy. |
| doi_str_mv | 10.1016/j.jchromb.2008.06.023 |
| format | article |
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mM Na
2CO
3, 1.0
mM NaHCO
3, and 1% acetonitrile, with a flow-rate of 0.7
ml/min. The procedure produced a linear curve over the concentration range of 50–2500
μg/ml. The development of the assay permitted the determination of therapeutic levels after oral administration of potassium bromide to dogs being treated for epilepsy.</description><identifier>ISSN: 1570-0232</identifier><identifier>EISSN: 1873-376X</identifier><identifier>DOI: 10.1016/j.jchromb.2008.06.023</identifier><identifier>PMID: 18599370</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Administration, Oral ; Analysis ; Analytical, structural and metabolic biochemistry ; Animals ; Anticonvulsants - administration & dosage ; Anticonvulsants - blood ; Anticonvulsants - therapeutic use ; Biological and medical sciences ; Bromide ; Bromides - administration & dosage ; Bromides - blood ; Bromides - therapeutic use ; Chromatography, Ion Exchange - methods ; Dog Diseases - blood ; Dog Diseases - drug therapy ; Dogs ; Epilepsy ; Epilepsy - drug therapy ; Epilepsy - veterinary ; Fundamental and applied biological sciences. Psychology ; General pharmacology ; Ion chromatography ; Medical sciences ; Pharmacology. Drug treatments ; Potassium Compounds - administration & dosage ; Potassium Compounds - blood ; Potassium Compounds - therapeutic use</subject><ispartof>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2008-07, Vol.870 (2), p.255-258</ispartof><rights>2008 Elsevier B.V.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c394t-7c741f8c88f75f47743ba987973283e8668813c2405bbc8205e07a54e65a89ce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20618760$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18599370$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cox, S.K.</creatorcontrib><creatorcontrib>Whiton, A.M.</creatorcontrib><creatorcontrib>Bowman, H.L.</creatorcontrib><title>Determination of bromide in canine plasma using ion chromatography</title><title>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences</title><addtitle>J Chromatogr B Analyt Technol Biomed Life Sci</addtitle><description>A new ion chromatographic procedure has been developed and validated for the determination of bromide in canine plasma. Following a simple dilution, samples were separated on a Metrosep A Supp 5 column. The mobile phase was an isocratic mixture of 2.2
mM Na
2CO
3, 1.0
mM NaHCO
3, and 1% acetonitrile, with a flow-rate of 0.7
ml/min. The procedure produced a linear curve over the concentration range of 50–2500
μg/ml. The development of the assay permitted the determination of therapeutic levels after oral administration of potassium bromide to dogs being treated for epilepsy.</description><subject>Administration, Oral</subject><subject>Analysis</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animals</subject><subject>Anticonvulsants - administration & dosage</subject><subject>Anticonvulsants - blood</subject><subject>Anticonvulsants - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Bromide</subject><subject>Bromides - administration & dosage</subject><subject>Bromides - blood</subject><subject>Bromides - therapeutic use</subject><subject>Chromatography, Ion Exchange - methods</subject><subject>Dog Diseases - blood</subject><subject>Dog Diseases - drug therapy</subject><subject>Dogs</subject><subject>Epilepsy</subject><subject>Epilepsy - drug therapy</subject><subject>Epilepsy - veterinary</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>Ion chromatography</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Potassium Compounds - administration & dosage</subject><subject>Potassium Compounds - blood</subject><subject>Potassium Compounds - therapeutic use</subject><issn>1570-0232</issn><issn>1873-376X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqFkE1LxDAQhoMo7vrxE5Re9NY6adokPYmunyB4UfAW0uxUs7TpmnSF_fdm3aJHTzMMzzszPIScUMgoUH6xyBbmw_ddneUAMgOeQc52yJRKwVIm-Ntu7EsBaRznE3IQwgKAChBsn0yoLKuKCZiS6xsc0HfW6cH2LumbpI5L7RwT6xKjnXWYLFsdOp2sgnXvyYb6OayH_t3r5cf6iOw1ug14PNZD8np3-zJ7SJ-e7x9nV0-pYVUxpMKIgjbSSNmIsimEKFitKykqwXLJUHIuJWUmL6CsayNzKBGELgvkpZaVQXZIzrd7l77_XGEYVGeDwbbVDvtVULxiLK8kj2C5BY3vQ_DYqKW3nfZrRUFt5KmFGuWpjTwFXEVLMXc6HljVHc7_UqOtCJyNgA5Gt43Xztjwy-XAo32-4S63HEYdXxa9CsaiMzi3Hs2g5r3955VvuwmPHQ</recordid><startdate>20080715</startdate><enddate>20080715</enddate><creator>Cox, S.K.</creator><creator>Whiton, A.M.</creator><creator>Bowman, H.L.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080715</creationdate><title>Determination of bromide in canine plasma using ion chromatography</title><author>Cox, S.K. ; Whiton, A.M. ; Bowman, H.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-7c741f8c88f75f47743ba987973283e8668813c2405bbc8205e07a54e65a89ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Administration, Oral</topic><topic>Analysis</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Animals</topic><topic>Anticonvulsants - administration & dosage</topic><topic>Anticonvulsants - blood</topic><topic>Anticonvulsants - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Bromide</topic><topic>Bromides - administration & dosage</topic><topic>Bromides - blood</topic><topic>Bromides - therapeutic use</topic><topic>Chromatography, Ion Exchange - methods</topic><topic>Dog Diseases - blood</topic><topic>Dog Diseases - drug therapy</topic><topic>Dogs</topic><topic>Epilepsy</topic><topic>Epilepsy - drug therapy</topic><topic>Epilepsy - veterinary</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General pharmacology</topic><topic>Ion chromatography</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Potassium Compounds - administration & dosage</topic><topic>Potassium Compounds - blood</topic><topic>Potassium Compounds - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cox, S.K.</creatorcontrib><creatorcontrib>Whiton, A.M.</creatorcontrib><creatorcontrib>Bowman, H.L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of chromatography. 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The mobile phase was an isocratic mixture of 2.2
mM Na
2CO
3, 1.0
mM NaHCO
3, and 1% acetonitrile, with a flow-rate of 0.7
ml/min. The procedure produced a linear curve over the concentration range of 50–2500
μg/ml. The development of the assay permitted the determination of therapeutic levels after oral administration of potassium bromide to dogs being treated for epilepsy.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>18599370</pmid><doi>10.1016/j.jchromb.2008.06.023</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1570-0232 |
| ispartof | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2008-07, Vol.870 (2), p.255-258 |
| issn | 1570-0232 1873-376X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69332986 |
| source | Elsevier |
| subjects | Administration, Oral Analysis Analytical, structural and metabolic biochemistry Animals Anticonvulsants - administration & dosage Anticonvulsants - blood Anticonvulsants - therapeutic use Biological and medical sciences Bromide Bromides - administration & dosage Bromides - blood Bromides - therapeutic use Chromatography, Ion Exchange - methods Dog Diseases - blood Dog Diseases - drug therapy Dogs Epilepsy Epilepsy - drug therapy Epilepsy - veterinary Fundamental and applied biological sciences. Psychology General pharmacology Ion chromatography Medical sciences Pharmacology. Drug treatments Potassium Compounds - administration & dosage Potassium Compounds - blood Potassium Compounds - therapeutic use |
| title | Determination of bromide in canine plasma using ion chromatography |
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