Glial cross-talk by transmembrane chemokines CX3CL1 and CXCL16

Abstract The transmembrane chemokines CX3CL1 and CXCL16 mediate chemotaxis and cell to cell adhesion by interaction with their receptors CXCR6 and CX3CR1, respectively. We here summarize reports on the expression, regulation and proteolytic processing of transmembrane chemokines by glial cells, thei...

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Bibliographic Details
Published in:Journal of neuroimmunology 2008-07, Vol.198 (1), p.92-97
Main Authors: Ludwig, Andreas, Mentlein, Rolf
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Astroglia
Cell Communication - physiology
Chemokine CXCL1 - physiology
Chemokine CXCL16
Chemokines
Chemokines, CXC - physiology
Chemotaxis
Gene Expression - physiology
Glial precursor cells
Glioma
Humans
Metalloproteinases
Neuroglia - physiology
Neuroinflammation
Neurology
Proliferation
Receptors, Scavenger - physiology
Shedding
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Summary:Abstract The transmembrane chemokines CX3CL1 and CXCL16 mediate chemotaxis and cell to cell adhesion by interaction with their receptors CXCR6 and CX3CR1, respectively. We here summarize reports on the expression, regulation and proteolytic processing of transmembrane chemokines by glial cells, their activity on glial cells/glial precursor cells and their role in glial cell cross-talk under physiological and pathophysiological conditions.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2008.04.024