Circulating antibodies and antigens correlate with egg counts in human fascioliasis

Summary We explored the relationships between specific IgG antibody levels and circulating E/S antigen to intensity of Fasciola infection in the human host. Twenty patients with patent infection and six healthy individuals were enrolled in the study. Intensity of infection was determined by repeated...

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Bibliographic Details
Published in:Tropical medicine & international health 1999-10, Vol.4 (10), p.691-694
Main Authors: Shehab, A. Y., Basha, L. M. Abou, El‐Morshedy, H. N., Abdel‐Fattah, M., Osman, M. M., Farag, H. F.
Format: Article
Language:English
Subjects:
antibodies
Antibodies, Helminth - blood
Antigens, Helminth - blood
Biological and medical sciences
circulating antigens
Diseases caused by trematodes
Distomatoses
egg counts
Enzyme-Linked Immunosorbent Assay
Fascioliasis - diagnosis
Fascioliasis - epidemiology
Fascioliasis - immunology
Fascioliasis - parasitology
Helminthic diseases
human fascioliasis
Humans
Infectious diseases
Medical sciences
Morbidity
Parasite Egg Count
Parasitic diseases
Serologic Tests
Tropical medicine
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Summary:Summary We explored the relationships between specific IgG antibody levels and circulating E/S antigen to intensity of Fasciola infection in the human host. Twenty patients with patent infection and six healthy individuals were enrolled in the study. Intensity of infection was determined by repeated egg counts in stools, while IgG antibodies against adult Fasciola gigantica somatic FI, FII and against E/S antigens were measured as ELISA O.D. readings. The level of circulating E/S antigens was determined by IELISA. Positivity as well as levels of antibodies and antigen correlated with infection intensity. These findings may disclose in the future a relation between morbidity in the acute phase and worm load.
ISSN:1360-2276
1365-3156
DOI:10.1046/j.1365-3156.1999.00466.x