The macrophage in chronic obstructive pulmonary disease

Macrophages are the predominant defense cell in the normal lung and during conditions associated with chronic inflammation such as COPD. However, the role of the macrophage in the development of COPD has been controversial. Scientific evidence from a variety of sources is emerging that supports a pr...

Full description

Saved in:
Bibliographic Details
Published in:American journal of respiratory and critical care medicine 1999-11, Vol.160 (5), p.29-32
Main Author: SHAPIRO, S. D
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Chronic obstructive pulmonary disease, asthma
Humans
Lung Diseases, Obstructive - immunology
Macrophage Inflammatory Proteins - physiology
Macrophages, Alveolar - immunology
Medical sciences
Metalloendopeptidases - physiology
Monocytes - immunology
Pneumology
Pulmonary Emphysema - immunology
Respiratory Mucosa - immunology
Smoking - adverse effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Macrophages are the predominant defense cell in the normal lung and during conditions associated with chronic inflammation such as COPD. However, the role of the macrophage in the development of COPD has been controversial. Scientific evidence from a variety of sources is emerging that supports a primary role for the macrophage in regulating the inflammatory response and tissue destruction associated with COPD. The role of macrophage proteinases in the development of emphysema, a major component of COPD, will be discussed. Shapiro SD. The macrophage in chronic obstructive pulmonary disease.
ISSN:1073-449X
1535-4970
DOI:10.1164/ajrccm.160.supplement_1.9