Influence of berberine on T-cell mediated immunity

The protoberberine alkaloid berberine is isolated as a main alkaloid from the roots and bark of Berberis vulgaris. Berberine strongly inhibited in vitro the proliferative response of mouse spleen cells to T-dependent mitogens concanavalin A (Con A) and phytochemagglutinin (PHA). Spleen cells obtaine...

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Bibliographic Details
Published in:Immunopharmacology and immunotoxicology 1999-11, Vol.21 (4), p.771-786
Main Authors: IVANOVSKA, N, PHILIPOV, S, HRISTOVA, M
Format: Article
Language:English
Subjects:
Aging - drug effects
Aging - immunology
alkaloids
Animals
Arthritis, Experimental - immunology
berberine
Berberine - pharmacology
Berberis vulgaris
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Candida albicans - immunology
Candidiasis - immunology
Candidiasis - mortality
Dose-Response Relationship, Immunologic
Female
Hypersensitivity, Delayed - immunology
Immunomodulators
Immunosuppressive Agents - pharmacology
Lymphocyte Activation - drug effects
Medical sciences
Mice
Mice, Inbred ICR
Mitogens - antagonists & inhibitors
Mitogens - pharmacology
Pharmacology. Drug treatments
Spleen - cytology
Spleen - drug effects
T-Lymphocytes - drug effects
T-Lymphocytes - immunology
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Summary:The protoberberine alkaloid berberine is isolated as a main alkaloid from the roots and bark of Berberis vulgaris. Berberine strongly inhibited in vitro the proliferative response of mouse spleen cells to T-dependent mitogens concanavalin A (Con A) and phytochemagglutinin (PHA). Spleen cells obtained from berberine-treated mice (10 mg/kg/3 days) expressed enhanced proliferative response to both mitogens. Berberine was applied to mice at different intervals before or after the induction of adjuvant arthritis (AIA) and Candida albicans (C. albicans) infection. The application of the alkaloid to new born mice (5 days after birth at a dose of 5 mg/kg/3 days) did not change the course of AIA and C. albicans infection. Its application at three 10 day intervals (5 mg/kg), starting from the 5 day after birth increased the joint inflammation in AIA. The host resistance to C. albicans infection was not affected, while the delayed type hypersensitivity (DTH)-reaction against the pathogen was enhanced. The alkaloid inhibited the development of AIA when applied after its onset (10 mg/kg from day +3 to +12 day). Berberine treatment during the ongoing infection did not influence its outcome (from +2 to +10 day).
ISSN:0892-3973
1532-2513
DOI:10.3109/08923979909007141