Fine-needle aspiration biopsy as an auxiliary diagnostic tool on intraoral minor salivary gland adenoid cystic carcinoma

Background Fine-needle aspiration biopsy (FNAB) is useful in diagnosis of major salivary gland adenoid cystic carcinoma (ACC), but it has been rarely reported on minor salivary gland ACC. Objective The aim of this study was to report the utility of FNAB on diagnosis of ACC involving minor salivary g...

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Published in:Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 2008-08, Vol.106 (2), p.242-245
Main Authors: Netto, Juliana de Noronha Santos, DDS, Miranda, Águida Maria Menezes Aguiar, DDS, MSc, da Silveira, Henrique Martins, DDS, PhD, dos Santos, Teresa Cristina Ribeiro Bartholomeu, DDS, MSc, Pires, Fábio Ramôa, DDS, PhD
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Biopsy, Fine-Needle - methods
Carcinoma, Adenoid Cystic - pathology
Cell Nucleus - ultrastructure
Cheek - pathology
Coloring Agents
Cytodiagnosis - methods
Cytoplasm - ultrastructure
Dentistry
Diagnosis, Differential
Extracellular Space
Female
Fluorescent Dyes
Humans
Male
Medical sciences
Middle Aged
Mouth Mucosa - pathology
Otorhinolaryngology. Stomatology
Palatal Neoplasms - pathology
Salivary Gland Neoplasms - pathology
Salivary Glands, Minor - pathology
Surgery
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:Background Fine-needle aspiration biopsy (FNAB) is useful in diagnosis of major salivary gland adenoid cystic carcinoma (ACC), but it has been rarely reported on minor salivary gland ACC. Objective The aim of this study was to report the utility of FNAB on diagnosis of ACC involving minor salivary glands. Study design Three patients presenting ACC involving the palate (2 cases) and buccal mucosa (1 case), with a mean age of 36 years and 2:1 female-to-male ratio, were included in the study. All of the patients were submitted to FNAB for diagnostic purposes. Results All smears were stained with hematoxylin-eosin, Papanicolaou, and Diff-Quik and showed the presence of small polyhedral cells with hyperchromatic nuclei and extracellular basophilic globular amorphous substance, compatible with ACC. Diagnosis of the 3 cases was subsequently confirmed through histopathology. Conclusion The FNAB was easy to perform and cost-effective, and proved to be an useful adjunctive tool in diagnosis of intraoral ACC.
ISSN:1079-2104
1528-395X
DOI:10.1016/j.tripleo.2008.04.015