Risk factors for growth and decline of lung function in asthmatic individuals up to age 42 years: A 30-year follow-up study

Little is known about factors determining the outcome of childhood asthma. The purpose of this longitudinal study was to assess the factors in childhood that determine the level of FEV(1) in early adulthood in asthmatic individuals, and to examine factors associated with decline in FEV(1) during adu...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 1999-12, Vol.160 (6), p.1830-1837
Main Authors: GROL, M. H, GERRITSEN, J, VONK, J. M, SCHOUTEN, J. P, KOËTER, G. H, RIJCKEN, B, POSTMA, D. S
Format: Article
Language:English
Subjects:
Adolescent
Adult
Allergic diseases
Asthma - blood
Asthma - immunology
Asthma - physiopathology
Biological and medical sciences
Bronchial Hyperreactivity - physiopathology
Bronchial Provocation Tests
Child
Child, Preschool
Chronic obstructive pulmonary disease, asthma
Eosinophils
Female
Follow-Up Studies
Forced Expiratory Volume
Humans
Immunoglobulin E - blood
Immunopathology
Leukocyte Count
Linear Models
Longitudinal Studies
Male
Medical sciences
Pneumology
Regression Analysis
Respiratory and ent allergic diseases
Respiratory Mechanics
Risk Factors
Skin Tests
Smoking
Spirometry
Vital Capacity
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Summary:Little is known about factors determining the outcome of childhood asthma. The purpose of this longitudinal study was to assess the factors in childhood that determine the level of FEV(1) in early adulthood in asthmatic individuals, and to examine factors associated with decline in FEV(1) during adulthood. Between 1966 and 1969, 119 allergic asthmatic subjects aged 5 to 14 yr were studied (Visit 1). Of these subjects, 101 (85%) were reinvestigated at ages 22 to 32 yr (Visit 2) and 32 to 42 yr (Visit 3). At the first survey and during follow-up, a standardized questionnaire was used, serum total IgE and peripheral blood eosinophils were measured, and physical examination, skin tests, lung function tests, and histamine challenge (provocative concentration causing a 10% decline in FEV(1); PC(10)) tests were performed according to the same protocol. Multiple linear regression analyses were performed with FEV(1) at Visit 2 and with the change of FEV(1) from Visit 2 to Visit 3 as outcome variables. A low FEV(1)% predicted at Visit 1 and PC(10)
ISSN:1073-449X
1535-4970
DOI:10.1164/ajrccm.160.6.9812100