Heterotopic sternum transplant in rats: A new model of a vascularized bone marrow transplantation

We introduced the heterotopic vascularized sternum transplant as a more simple and pure alternative to allogeneic hind limb transplantation for the study of bone marrow transplantation. We report the clinical and histopathological manifestations after transplantation of syngeneic and allogeneic ster...

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Bibliographic Details
Published in:Microsurgery 1999, Vol.19 (7), p.330-334
Main Authors: Santiago, Sergio F., de Faria, Werviston, Khan, Taqi F. Toufeeq, Gandia, Carlos E., Misiakos, Evangelos P., Ferrer, Luis, Ruiz, Phillip, Coleman, Laurence, Fernandez, Hugo F., Miller, Joshua, Ricordi, Camillo, Tzakis, Andreas G.
Format: Article
Language:English
Subjects:
Animals
Bone Marrow Transplantation - immunology
Bone Transplantation - immunology
Bone Transplantation - methods
Female
Immunosuppression
Male
Rats
Rats, Inbred Lew
Sternum - transplantation
Transplantation, Heterotopic
Transplantation, Isogeneic
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Summary:We introduced the heterotopic vascularized sternum transplant as a more simple and pure alternative to allogeneic hind limb transplantation for the study of bone marrow transplantation. We report the clinical and histopathological manifestations after transplantation of syngeneic and allogeneic sternal grafts with and without immunossupression with FK‐506. Syngeneic grafts maintained normal histology, whereas allografts showed rejection, which was prevented by FK‐506. FK‐506‐treated allografts developed chimerism that was present throughout the observation period. Transplantation of the sternum may be a valuable model to study vascularized bone marrow transplantation and its effects on repopulation of bone marrow of the host, chimerism, and tolerance. © 1999 Wiley‐Liss, Inc. MICROSURGERY 19:330–334 1999
ISSN:0738-1085
1098-2752
DOI:10.1002/(SICI)1098-2752(1999)19:7<330::AID-MICR8>3.0.CO;2-I