Age-Dependent Prevalence and Frequency of Circulating t(14;18)-Positive Cells in the Peripheral Blood of Healthy Individuals

Circulating t(14;18)-positive cells were detected by quantitative real-time polymerase chain reaction on DNA isolated from peripheral blood mononuclear cells (PBMNCs) from 644 healthy individuals between 40 years. These results are discussed in relation to the low incidence of follicular lymphoma.

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Bibliographic Details
Published in:Journal of the National Cancer Institute. Monographs 2008-07, Vol.2008 (39), p.44-47
Main Authors: Dölken, Gottfried, Dölken, Lars, Hirt, Carsten, Fusch, Christoph, Rabkin, Charles S., Schüler, Frank
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Aging - physiology
Biological and medical sciences
Blood Cells
Blood Donors
Child
Child, Preschool
Chromosome aberrations
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 18
Female
Humans
Infant
Leukocytes, Mononuclear - physiology
Male
Medical genetics
Medical sciences
Middle Aged
Polymerase Chain Reaction
Prevalence
Translocation, Genetic
Tumors
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Description
Summary:Circulating t(14;18)-positive cells were detected by quantitative real-time polymerase chain reaction on DNA isolated from peripheral blood mononuclear cells (PBMNCs) from 644 healthy individuals between 40 years. These results are discussed in relation to the low incidence of follicular lymphoma.
ISSN:1052-6773
1745-6614
DOI:10.1093/jncimonographs/lgn005