Eotaxin and impaired lung function in asthma

We performed an association study of plasma eotaxin levels, eosinophil counts, total IgE levels, asthma diagnosis, and lung function in an ethnically diverse and geographically dispersed population. We studied 515 asthmatic and 519 normal subjects, none of whom was taking inhaled or oral corticoster...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 1999-12, Vol.160 (6), p.1952-1956
Main Authors: NAKAMURA, H, WEISS, S. T, ISRAEL, E, LUSTER, A. D, DRAZEN, J. M, LILLY, C. M
Format: Article
Language:English
Subjects:
Adult
Asthma - blood
Asthma - diagnosis
Asthma - immunology
Asthma - physiopathology
Biological and medical sciences
Biomarkers - blood
Chemokine CCL11
Chemokines, CC
Chemotactic Factors, Eosinophil - blood
Chronic obstructive pulmonary disease, asthma
Confidence Intervals
Cytokines - blood
Eosinophils
Female
Forced Expiratory Volume
Humans
Immunoglobulin E - blood
Leukocyte Count
Male
Medical sciences
Middle Aged
Odds Ratio
Pneumology
Regression Analysis
Respiratory Mechanics
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Summary:We performed an association study of plasma eotaxin levels, eosinophil counts, total IgE levels, asthma diagnosis, and lung function in an ethnically diverse and geographically dispersed population. We studied 515 asthmatic and 519 normal subjects, none of whom was taking inhaled or oral corticosteroids. Logistic regression analysis demonstrated a direct relationship between asthma diagnosis and eotaxin levels (p < 0.0001). The odds of an asthma diagnosis increased with eotaxin quartile, with the highest quartile having an odds ratio of 5.4 (95% CI 3.2 to 9.2, p < 0.001) compared with the lowest eotaxin quartile. Eotaxin levels were inversely related to lung function (p < 0.001), with the mean percent predicted FEV(1) in the highest eotaxin quartile being 13.5 percentage points (SEM 2.1, p < 0.001) less than that in the lowest quartile. Plasma eotaxin levels were associated with asthma and inversely related to lung function independent of age, race, sex, or smoking status. When combined with eosinophil counts and IgE levels, eotaxin levels contributed to the odds of an asthma diagnosis and of impaired lung function. Our results are the first to associate eotaxin levels with asthma diagnosis and compromised lung function in a large geographically and ethnically diverse population.
ISSN:1073-449X
1535-4970
DOI:10.1164/ajrccm.160.6.9811089