Self-propelled particle model for cell-sorting phenomena

A self-propelled particle model is introduced to study cell sorting occurring in some living organisms. This allows us to evaluate the influence of intrinsic cell motility separately from differential adhesion with fluctuations, a mechanism previously shown to be sufficient to explain a variety of c...

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Bibliographic Details
Published in:Physical review letters 2008-06, Vol.100 (24), p.248702-248702
Main Authors: Belmonte, Julio M, Thomas, Gilberto L, Brunnet, Leonardo G, de Almeida, Rita M C, Chaté, Hugues
Format: Article
Language:English
Subjects:
Animals
Cell Adhesion - physiology
Cell Movement - physiology
Hydra - cytology
Hydra - physiology
Models, Biological
Regeneration - physiology
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Summary:A self-propelled particle model is introduced to study cell sorting occurring in some living organisms. This allows us to evaluate the influence of intrinsic cell motility separately from differential adhesion with fluctuations, a mechanism previously shown to be sufficient to explain a variety of cell rearrangement processes. We find that the tendency of cells to actively follow their neighbors greatly reduces segregation time scales. A finite-size analysis of the sorting process reveals clear algebraic growth laws as in physical phase-ordering processes, albeit with unusual scaling exponents.
ISSN:0031-9007
DOI:10.1103/PhysRevLett.100.248702