Methamphetamine-induced stereotypies in newly-hatched decerebrated domestic chicks

Metamphetamine in high dose has been reported to induce stereotypic behavior of abnormal form in the pigeon and domestic chick. A number of reports suggested that the target of metamphetamine was the paleostriatal complex, the highest motor center of the avian brain. The present study tested this hy...

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Bibliographic Details
Published in:Neurochemical research 1999-12, Vol.24 (12), p.1563-1569
Main Authors: KABAI, P, LIKER, A, CSILLAG, A
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Chickens
Decerebrate State
Drug addictions
Medical sciences
Methamphetamine - pharmacology
Stereotyped Behavior - drug effects
Stereotyped Behavior - physiology
Telencephalon - physiology
Toxicology
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Summary:Metamphetamine in high dose has been reported to induce stereotypic behavior of abnormal form in the pigeon and domestic chick. A number of reports suggested that the target of metamphetamine was the paleostriatal complex, the highest motor center of the avian brain. The present study tested this hypothesis by treating newly-hatched domestic chicks with high dose of metamphetamine (10 mg/kg b.w.) after complete decerebration or sham operation. Stereotypic mandibulations were observed both in sham-operated and in decerebrated birds in similar form following methamphetamine treatment. The results suggested that brainstem pattern generators remain responsive to dopaminergic stimuli in the absence of the main telencephalic (striatal) targets.
ISSN:0364-3190
1573-6903
DOI:10.1023/A:1021108300731