Nitric Oxide Formation Is Inversely Related to Serum Levels of Antiangiogenic Factors Soluble Fms-Like Tyrosine Kinase-1 and Soluble Endogline in Preeclampsia

Deficient NO formation has been implicated in hypertensive disorders of pregnancy. However, no previous study has compared the circulating nitrite concentrations in healthy pregnant women with those found in hypertensive disorders of pregnancy. Moreover, 2 antiangiogenic factors produced in the plac...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2008-08, Vol.52 (2), p.402-407
Main Authors: Sandrim, Valeria C, Palei, Ana C.T, Metzger, Ingrid F, Gomes, Valeria A, Cavalli, Ricardo C, Tanus-Santos, Jose E
Format: Article
Language:English
Subjects:
Adult
Antigens, CD - blood
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Biomarkers - blood
Blood and lymphatic vessels
Bones, joints and connective tissue. Antiinflammatory agents
Cardiology. Vascular system
Case-Control Studies
Endoglin
Female
Humans
Medical sciences
Nitric Oxide - blood
Nitric Oxide - metabolism
Pharmacology. Drug treatments
Pre-Eclampsia - blood
Pre-Eclampsia - diagnosis
Predictive Value of Tests
Pregnancy
Pregnancy Outcome
Probability
Receptors, Cell Surface - blood
Reference Values
Risk Assessment
Sensitivity and Specificity
Severity of Illness Index
Vascular Endothelial Growth Factor Receptor-1 - blood
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Summary:Deficient NO formation has been implicated in hypertensive disorders of pregnancy. However, no previous study has compared the circulating nitrite concentrations in healthy pregnant women with those found in hypertensive disorders of pregnancy. Moreover, 2 antiangiogenic factors produced in the placenta (soluble fms-like tyrosine kinase-1 and soluble endogline) may affect NO formation during pregnancy. Here, we hypothesized that lower concentrations of markers of NO formation exist in hypertensive disorders of pregnancy and that inverse relationships exist between these markers and soluble fms-like tyrosine kinase-1 or soluble endogline. In this cross-sectional study, we compared 58 healthy pregnant women with 56 gestational hypertensive subjects and 45 preeclamptic patients. We measured plasma and whole blood nitrite concentrations using an ozone-based chemiluminescence assay and serum soluble fms-like tyrosine kinase-1 and soluble endogline concentrations using enzyme immunoassays. Whole blood nitrite levels were significantly lower in gestational hypertensive subjects and preeclamptic patients (−36% and −58%, respectively; both P
ISSN:0194-911X
1524-4563
DOI:10.1161/HYPERTENSIONAHA.108.115006