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Where are the receptors for Streptococcus pyogenes located on the tonsillar surface epithelium?
Streptococcus pyogenes is the most frequent causative agent of acute pharyngotonsillitis (AT). The first events in the etiopathogenesis of an AT infection caused by these bacterial pathogens are their penetration through the mucus film covering the oropharyngeal mucosa, and their attachment to the s...
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Published in: | International journal of pediatric otorhinolaryngology 1999-10, Vol.50 (1), p.37-43 |
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creator | Lilja, Markus Silvola, Juha Räisänen, Simo Stenfors, Lars-Eric |
description | Streptococcus pyogenes is the most frequent causative agent of acute pharyngotonsillitis (AT). The first events in the etiopathogenesis of an AT infection caused by these bacterial pathogens are their penetration through the mucus film covering the oropharyngeal mucosa, and their attachment to the surface epithelium. Adherence of
S. pyogenes to tonsillar epithelial cells is a precondition for bacterial colonisation, for triggering off cell activation, internalising of bacteria into the epithelial cells and cytokine release from the epithelial cells with subsequent induction of an inflammatory reaction in underlying tissues. Scanning and transmission electron microscopic studies revealed that the surface epithelium of the human palatine tonsils consisted of a weakly keratinized, stratified squamous epithelium built up of pentangular cells where the apical cell surface formed an irregular pattern of microridges. The distance between two adjacent microridges was roughly one-third of the diameter of a
S. pyogenes bacterium. By using gold-labelled antiserum to
S. pyogenes, we showed that the target region for these pathogens on the epithelial cells during an on-going AT infection was located on the crests of the microridges where bacterial pili made adhesin-receptor contact with the tonsillar surface epithelium. |
doi_str_mv | 10.1016/S0165-5876(99)00221-9 |
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S. pyogenes to tonsillar epithelial cells is a precondition for bacterial colonisation, for triggering off cell activation, internalising of bacteria into the epithelial cells and cytokine release from the epithelial cells with subsequent induction of an inflammatory reaction in underlying tissues. Scanning and transmission electron microscopic studies revealed that the surface epithelium of the human palatine tonsils consisted of a weakly keratinized, stratified squamous epithelium built up of pentangular cells where the apical cell surface formed an irregular pattern of microridges. The distance between two adjacent microridges was roughly one-third of the diameter of a
S. pyogenes bacterium. By using gold-labelled antiserum to
S. pyogenes, we showed that the target region for these pathogens on the epithelial cells during an on-going AT infection was located on the crests of the microridges where bacterial pili made adhesin-receptor contact with the tonsillar surface epithelium.</description><identifier>ISSN: 0165-5876</identifier><identifier>EISSN: 1872-8464</identifier><identifier>DOI: 10.1016/S0165-5876(99)00221-9</identifier><identifier>PMID: 10596885</identifier><identifier>CODEN: IPOTDJ</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ireland Ltd</publisher><subject>Adolescent ; Adult ; Bacterial adherence ; Bacterial Adhesion ; Biological and medical sciences ; Biopsy ; Ent. Stomatology ; Epithelium - microbiology ; Epithelium - pathology ; Epithelium - ultrastructure ; Female ; Group A β-haemolytic streptococci ; Humans ; Inflammation ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Microscopy, Electron - methods ; Non tumoral diseases ; Otorhinolaryngology. Stomatology ; Palatine Tonsil - microbiology ; Palatine Tonsil - pathology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Pharyngitis - microbiology ; Receptors ; Receptors, Cell Surface - physiology ; Streptococcal Infections - physiopathology ; Streptococcus pyogenes - isolation & purification ; Streptococcus pyogenes - pathogenicity ; Streptococcus pyogenes - ultrastructure ; Tonsillitis - microbiology ; Tonsillitis acuta ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>International journal of pediatric otorhinolaryngology, 1999-10, Vol.50 (1), p.37-43</ispartof><rights>1999 Elsevier Science Ireland Ltd</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-5da1c312eeb1759eac9a639a9300b2b215bf5f5c18537e9a637a8d65141dd47c3</citedby><cites>FETCH-LOGICAL-c390t-5da1c312eeb1759eac9a639a9300b2b215bf5f5c18537e9a637a8d65141dd47c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1989594$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10596885$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lilja, Markus</creatorcontrib><creatorcontrib>Silvola, Juha</creatorcontrib><creatorcontrib>Räisänen, Simo</creatorcontrib><creatorcontrib>Stenfors, Lars-Eric</creatorcontrib><title>Where are the receptors for Streptococcus pyogenes located on the tonsillar surface epithelium?</title><title>International journal of pediatric otorhinolaryngology</title><addtitle>Int J Pediatr Otorhinolaryngol</addtitle><description>Streptococcus pyogenes is the most frequent causative agent of acute pharyngotonsillitis (AT). The first events in the etiopathogenesis of an AT infection caused by these bacterial pathogens are their penetration through the mucus film covering the oropharyngeal mucosa, and their attachment to the surface epithelium. Adherence of
S. pyogenes to tonsillar epithelial cells is a precondition for bacterial colonisation, for triggering off cell activation, internalising of bacteria into the epithelial cells and cytokine release from the epithelial cells with subsequent induction of an inflammatory reaction in underlying tissues. Scanning and transmission electron microscopic studies revealed that the surface epithelium of the human palatine tonsils consisted of a weakly keratinized, stratified squamous epithelium built up of pentangular cells where the apical cell surface formed an irregular pattern of microridges. The distance between two adjacent microridges was roughly one-third of the diameter of a
S. pyogenes bacterium. By using gold-labelled antiserum to
S. pyogenes, we showed that the target region for these pathogens on the epithelial cells during an on-going AT infection was located on the crests of the microridges where bacterial pili made adhesin-receptor contact with the tonsillar surface epithelium.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Bacterial adherence</subject><subject>Bacterial Adhesion</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Ent. Stomatology</subject><subject>Epithelium - microbiology</subject><subject>Epithelium - pathology</subject><subject>Epithelium - ultrastructure</subject><subject>Female</subject><subject>Group A β-haemolytic streptococci</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microscopy, Electron - methods</subject><subject>Non tumoral diseases</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Palatine Tonsil - microbiology</subject><subject>Palatine Tonsil - pathology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Pharyngitis - microbiology</subject><subject>Receptors</subject><subject>Receptors, Cell Surface - physiology</subject><subject>Streptococcal Infections - physiopathology</subject><subject>Streptococcus pyogenes - isolation & purification</subject><subject>Streptococcus pyogenes - pathogenicity</subject><subject>Streptococcus pyogenes - ultrastructure</subject><subject>Tonsillitis - microbiology</subject><subject>Tonsillitis acuta</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>0165-5876</issn><issn>1872-8464</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNqFkE1P3DAQhq2qqCzQn1DkQ1XRQ8BOYidzQhWiLdJKHBbUo-VMJsVVNg52gsS_x_shyo2DbVnzvDOjh7EvUpxLIfXFKl0qU3WlzwC-C5HnMoMPbCHrKs_qUpcf2eIVOWRHMf4TQlZCqU_sUAoFuq7Vgpk_DxSI23SmB-KBkMbJh8g7H_hqCpsfesQ58vHZ_6WBIu892ola7odtZvJDdH1vA49z6CwSp9GlQu_m9eUJO-hsH-nz_j1m9z-v765-Z8vbXzdXP5YZFiCmTLVWYiFzokZWCsgiWF2AhUKIJm9yqZpOdQplrYqKNrXK1q1WspRtW1ZYHLNvu75j8I8zxcmsXURKaw3k52g0FEpo0AlUOxCDjzFQZ8bg1jY8GynMxqzZmjUbbQbAbM0aSLnT_YC5WVP7JrVTmYCve8BGtH0X7IAu_uegBgVlwi53GCUbT46CiehoQGpdkj-Z1rt3NnkBGAyWZw</recordid><startdate>19991015</startdate><enddate>19991015</enddate><creator>Lilja, Markus</creator><creator>Silvola, Juha</creator><creator>Räisänen, Simo</creator><creator>Stenfors, Lars-Eric</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>19991015</creationdate><title>Where are the receptors for Streptococcus pyogenes located on the tonsillar surface epithelium?</title><author>Lilja, Markus ; Silvola, Juha ; Räisänen, Simo ; Stenfors, Lars-Eric</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-5da1c312eeb1759eac9a639a9300b2b215bf5f5c18537e9a637a8d65141dd47c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Bacterial adherence</topic><topic>Bacterial Adhesion</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Ent. Stomatology</topic><topic>Epithelium - microbiology</topic><topic>Epithelium - pathology</topic><topic>Epithelium - ultrastructure</topic><topic>Female</topic><topic>Group A β-haemolytic streptococci</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microscopy, Electron - methods</topic><topic>Non tumoral diseases</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Palatine Tonsil - microbiology</topic><topic>Palatine Tonsil - pathology</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Pharyngitis - microbiology</topic><topic>Receptors</topic><topic>Receptors, Cell Surface - physiology</topic><topic>Streptococcal Infections - physiopathology</topic><topic>Streptococcus pyogenes - isolation & purification</topic><topic>Streptococcus pyogenes - pathogenicity</topic><topic>Streptococcus pyogenes - ultrastructure</topic><topic>Tonsillitis - microbiology</topic><topic>Tonsillitis acuta</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lilja, Markus</creatorcontrib><creatorcontrib>Silvola, Juha</creatorcontrib><creatorcontrib>Räisänen, Simo</creatorcontrib><creatorcontrib>Stenfors, Lars-Eric</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>International journal of pediatric otorhinolaryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lilja, Markus</au><au>Silvola, Juha</au><au>Räisänen, Simo</au><au>Stenfors, Lars-Eric</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Where are the receptors for Streptococcus pyogenes located on the tonsillar surface epithelium?</atitle><jtitle>International journal of pediatric otorhinolaryngology</jtitle><addtitle>Int J Pediatr Otorhinolaryngol</addtitle><date>1999-10-15</date><risdate>1999</risdate><volume>50</volume><issue>1</issue><spage>37</spage><epage>43</epage><pages>37-43</pages><issn>0165-5876</issn><eissn>1872-8464</eissn><coden>IPOTDJ</coden><abstract>Streptococcus pyogenes is the most frequent causative agent of acute pharyngotonsillitis (AT). The first events in the etiopathogenesis of an AT infection caused by these bacterial pathogens are their penetration through the mucus film covering the oropharyngeal mucosa, and their attachment to the surface epithelium. Adherence of
S. pyogenes to tonsillar epithelial cells is a precondition for bacterial colonisation, for triggering off cell activation, internalising of bacteria into the epithelial cells and cytokine release from the epithelial cells with subsequent induction of an inflammatory reaction in underlying tissues. Scanning and transmission electron microscopic studies revealed that the surface epithelium of the human palatine tonsils consisted of a weakly keratinized, stratified squamous epithelium built up of pentangular cells where the apical cell surface formed an irregular pattern of microridges. The distance between two adjacent microridges was roughly one-third of the diameter of a
S. pyogenes bacterium. By using gold-labelled antiserum to
S. pyogenes, we showed that the target region for these pathogens on the epithelial cells during an on-going AT infection was located on the crests of the microridges where bacterial pili made adhesin-receptor contact with the tonsillar surface epithelium.</abstract><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>10596885</pmid><doi>10.1016/S0165-5876(99)00221-9</doi><tpages>7</tpages></addata></record> |
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subjects | Adolescent Adult Bacterial adherence Bacterial Adhesion Biological and medical sciences Biopsy Ent. Stomatology Epithelium - microbiology Epithelium - pathology Epithelium - ultrastructure Female Group A β-haemolytic streptococci Humans Inflammation Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Microscopy, Electron - methods Non tumoral diseases Otorhinolaryngology. Stomatology Palatine Tonsil - microbiology Palatine Tonsil - pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Pharyngitis - microbiology Receptors Receptors, Cell Surface - physiology Streptococcal Infections - physiopathology Streptococcus pyogenes - isolation & purification Streptococcus pyogenes - pathogenicity Streptococcus pyogenes - ultrastructure Tonsillitis - microbiology Tonsillitis acuta Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
title | Where are the receptors for Streptococcus pyogenes located on the tonsillar surface epithelium? |
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