Selection of refractory and permissive strains of Aedes triseriatus (Diptera: Culicidae) for transovarial transmission of La Crosse virus

The genetic basis of transovarial transmission of La Crosse virus in Aedes triseriatus (Say) was investigated through selection experiments on 2 mosquito strains. One strain was subject to selection for transovarial refractoriness, the other for permissiveness to transovarial transmission. Response...

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Bibliographic Details
Published in:Journal of medical entomology 1999-11, Vol.36 (6), p.671-678
Main Authors: Graham, D.H, Holmes, J.L, Higgs, S, Beaty, B.J, Black, W.C. IV
Format: Article
Language:English
Subjects:
Aedes - genetics
Aedes - virology
Aedes triseriatus
Animals
artificial selection
Biological and medical sciences
California encephalitis virus
Cell Line
Cricetinae
crossing
Culicidae
Disease transmission
disease vectors
Encephalitis, California - transmission
Female
filial infection rate
Fundamental and applied biological sciences. Psychology
genetic models
genetic techniques and protocols
Genetics of eukaryotes. Biological and molecular evolution
Health aspects
Infection
Invertebrata
La Crosse virus
La Crosse virus - physiology
Larva - virology
Male
Mosquitoes
Ovary - virology
permissiveness
Population genetics, reproduction patterns
refractoriness
responses
Species Specificity
strain differences
transovarial transmission
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Summary:The genetic basis of transovarial transmission of La Crosse virus in Aedes triseriatus (Say) was investigated through selection experiments on 2 mosquito strains. One strain was subject to selection for transovarial refractoriness, the other for permissiveness to transovarial transmission. Response to selection for a low filial infection rate was rapid, decreasing from 18 to 3% in 3 generations. However, no response to selection for permissiveness was observed in the other strain; the average filial infection rates through 4 generations fluctuated between 25 and 40%. By contrast, the transovarial transmission rate in both strains showed a consistent response to selection in both directions. These patterns are consistent with a model in which transovarial transmission is controlled by a single genetic locus and permissiveness is conditioned by dominant alleles; whereas the filial infection rate is nongenetic and influenced by stochastic factors in the mosquito and virus.
ISSN:0022-2585
1938-2928
DOI:10.1093/jmedent/36.6.671