Daphniphyllum and Diterpenoid Alkaloids from Daphniphyllum longeracemosum

Four new Daphniphyllum alkaloids, daphlongamines A−D (1−4), were isolated from the fruits of Daphniphyllum longeracemosum. Their structures were characterized by spectroscopic methods, especially 2D NMR techniques. A single-crystal X-ray diffraction analysis was used to confirm the stereochemistry o...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2008-07, Vol.71 (7), p.1202-1206
Main Authors: Li, Chun-Shun, Di, Ying-Tong, Mu, Shu-Zhen, He, Hong-Ping, Zhang, Qiang, Fang, Xin, Zhang, Yu, Li, Shun-Lin, Lu, Yang, Gong, Yan-Qing, Hao, Xiao-Jiang
Format: Article
Language:English
Subjects:
aconitine diterpenes
alkaloids
Alkaloids - chemistry
Alkaloids - isolation & purification
Biological and medical sciences
chemical structure
Crystallography, X-Ray
daphlongamine
Daphniphyllum
Daphniphyllum longeracemosum
Diterpenes - chemistry
Diterpenes - isolation & purification
diterpenoids
Drugs, Chinese Herbal - chemistry
Drugs, Chinese Herbal - isolation & purification
General pharmacology
Medical sciences
Molecular Conformation
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Saxifragaceae - chemistry
spectral analysis
stereochemistry
veatchine diterpenes
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Summary:Four new Daphniphyllum alkaloids, daphlongamines A−D (1−4), were isolated from the fruits of Daphniphyllum longeracemosum. Their structures were characterized by spectroscopic methods, especially 2D NMR techniques. A single-crystal X-ray diffraction analysis was used to confirm the stereochemistry of 3. Remarkably, this is the first report of aconitine- and veatchine-type diterpenoid alkaloids from the genus Daphniphyllum.
ISSN:0163-3864
1520-6025
DOI:10.1021/np8001332