Role of Cysteine Cathepsins in Matrix Degradation and Cell Signalling

Cysteine cathepsins participate in extracellular matrix (ECM) degradation and remodelling and thus influence important cellular processes such as cell transformation and differentiation, motility, adhesion, invasion, angiogenesis, and metastasis. Also, cathepsins are involved in cell signalling and...

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Bibliographic Details
Published in:Connective Tissue Research 2008-01, Vol.49 (3-4), p.193-196
Main Authors: Obermajer, Nataša, Jevnikar, Zala, Doljak, Bojan, Kos, Janko
Format: Article
Language:English
Subjects:
Animals
Cathepsin
Cathepsins - metabolism
Cell Adhesion
Cell Movement
Cysteine
Extracellular Matrix - metabolism
Humans
Integrin
Migration
Neovascularization, Physiologic
Proteolysis
Signal Transduction
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Summary:Cysteine cathepsins participate in extracellular matrix (ECM) degradation and remodelling and thus influence important cellular processes such as cell transformation and differentiation, motility, adhesion, invasion, angiogenesis, and metastasis. Also, cathepsins are involved in cell signalling and are capable of activating specific cell receptors and growth factors or liberating them from the ECM. In this review we emphasize recent studies on cathepsins in regard to ECM degradation and cell signalling.
ISSN:0300-8207
1521-0456
1607-8438
DOI:10.1080/03008200802143158