Aromatic Amino Acids Providing Characteristic Motifs in the Raman and SERS Spectroscopy of Peptides

Raman and surface-enhanced Raman spectroscopies (SERS) are potentially important tools in the characterization of biomolecules such as proteins and DNA. In this work, SERS spectra of three cysteine-containing aromatic peptides: tryptophan−cysteine, tyrosine−cysteine, and phenylalanine−cysteine, boun...

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Bibliographic Details
Published in:The journal of physical chemistry. B 2008-07, Vol.112 (30), p.9158-9164
Main Authors: Wei, Fang, Zhang, Dongmao, Halas, Naomi J, Hartgerink, Jeffrey D
Format: Article
Language:English
Subjects:
Amino Acid Motifs
Amino Acid Sequence
Amino Acids, Aromatic - chemistry
B: Biophysical Chemistry
Carrier Proteins - chemistry
Cysteine - chemistry
Molecular Sequence Data
Peptides - chemistry
Reproducibility of Results
Spectrum Analysis, Raman - methods
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Summary:Raman and surface-enhanced Raman spectroscopies (SERS) are potentially important tools in the characterization of biomolecules such as proteins and DNA. In this work, SERS spectra of three cysteine-containing aromatic peptides: tryptophan−cysteine, tyrosine−cysteine, and phenylalanine−cysteine, bound to Au nanoshell substrates, were obtained, and compared to their respective normal Raman spectra. While the linewidths of the SERS peaks are significantly broadened (up to 70%), no significant spectral shifts (
ISSN:1520-6106
1520-5207
DOI:10.1021/jp8025732