Factors affecting successful closure of hemodynamically significant patent ductus arteriosus with indomethacin in extremely low birth weight infants

Background The incidence of patent ductus arteriosus (PDA) is high in extremely low birth weight (ELBW) infants. Indomethacin has been widely used in the prophylaxis and treatment of hemodynamically significant PDA. This retrospective study was undertaken to identify factors such as birth weight, ge...

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Bibliographic Details
Published in:World journal of pediatrics : WJP 2008-05, Vol.4 (2), p.91-96
Main Authors: Yang, Chuan-Zhong, Lee, Jiun
Format: Article
Language:English
Subjects:
Birth Weight
Causality
Cohort Studies
Critical Care Medicine
Ductus Arteriosus, Patent - drug therapy
Ductus Arteriosus, Patent - epidemiology
Female
Fetal Growth Retardation - epidemiology
Gestational Age
Humans
Imaging
Indomethacin - therapeutic use
Infant, Extremely Low Birth Weight
Infant, Newborn
Infant, Premature
Intensive
Male
Maternal and Child Health
Medicine
Medicine & Public Health
Original Article
Pediatric Surgery
Pediatrics
Prostaglandin Antagonists - therapeutic use
Radiology
Retrospective Studies
Sex Factors
Singapore - epidemiology
Surgery
Treatment Outcome
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Summary:Background The incidence of patent ductus arteriosus (PDA) is high in extremely low birth weight (ELBW) infants. Indomethacin has been widely used in the prophylaxis and treatment of hemodynamically significant PDA. This retrospective study was undertaken to identify factors such as birth weight, gestational age, gender, fetal growth retardation, ductal size, timing of the first dose of indomethacin and side effects of indomethacin, which may affect the successful closure of the PDA with indomethacin in ELBW infants. Methods A cohort of 139 ELBW infants who had received indomethacin treatment for PDA during a consecutive period of more than three years (September 2000 to December 2003) was retrospectively analyzed. Results Administration of indomethacin was associated with closure of PDA in 108 (77.7%) of 139 ELBW infants, and only 19.4% of infants required surgical ligation of the ductus eventually. There was no significant relationship between closure of PDA with gestational age, gender, fetal growth retardation, and ductal size. A higher birth weight and early use of indomethacin after birth could significantly increase the closure rate of PDA ( P
ISSN:1708-8569
DOI:10.1007/s12519-008-0017-7