Differential effects of losartan and doxazosin on vascular function in senescent spontaneously hypertensive rats

We evaluated the effects of treatment for 12 weeks with 10 mg/kg/day of either losartan or doxazosin on vascular function in senescent spontaneous hypertensive rats (SHR). Both doxazosin and losartan reduced blood pressure, although the former was more effective. In contrast, both drugs reduced rela...

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Bibliographic Details
Published in:American journal of hypertension 1999-11, Vol.12 (11), p.1105-1108
Main Authors: Maeso, Rosaura, Navarro-Cid, Josefa, Rodrigo, Elena, Ruilope, Luis Miguel, Lahera, Vicente, Cachofeiro, Victoria
Format: Article
Language:English
Subjects:
Acetylcholine - pharmacology
Adrenergic alpha-Antagonists - pharmacology
Aging
Angiotensin II - metabolism
Animals
Antihypertensive agents
Antihypertensive Agents - pharmacology
Aorta - drug effects
Aorta - metabolism
Aorta - physiopathology
Biological and medical sciences
Blood Pressure - drug effects
Cardiovascular system
Doxazosin - pharmacology
endothelium
Endothelium, Vascular - drug effects
Endothelium, Vascular - metabolism
hypertension
Hypertension - drug therapy
Hypertension - metabolism
Hypertension - physiopathology
Losartan - pharmacology
Male
Medical sciences
Nitrates - blood
Nitroprusside - pharmacology
Pharmacology. Drug treatments
Rats
Rats, Sprague-Dawley
Receptor, Angiotensin, Type 1
Receptor, Angiotensin, Type 2
Receptors, Angiotensin - drug effects
Receptors, Angiotensin - metabolism
Vasodilation - drug effects
Vasodilator Agents - pharmacology
vasorelaxation
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Summary:We evaluated the effects of treatment for 12 weeks with 10 mg/kg/day of either losartan or doxazosin on vascular function in senescent spontaneous hypertensive rats (SHR). Both doxazosin and losartan reduced blood pressure, although the former was more effective. In contrast, both drugs reduced relative aortic weight and increased plasma nitrates to a similar extent. Losartan, but not doxazosin, increased the magnitude of the response to acetylcholine (10 −9 to 10 −5 mol/L). Both treatments increased relaxations to sodium nitroprusside (10 −10 to 10 −6 mol/L). These data show that losartan may possess advantages over doxazosin in improving vascular function in senescent SHR. This report emphasizes the importance of angiotensin II in vascular function alterations induced by aging in SHR.
ISSN:0895-7061
1879-1905
1941-7225
DOI:10.1016/S0895-7061(99)00086-2