MIB-1 in Endometrial Carcinoma: Prognostic Significance with 5-Year Follow-Up

• Published in: Gynecologic oncology 1999-12, Vol.75 (3), p.432-436
• Main Authors: Geisler, John P., Geisler, Hans E., Miller, Greg A., Wiemann, Michael C., Zhou, Zhen, Crabtree, William
• Format: Article
• Language: English
• Subjects: Antibodies, Monoclonal - immunology; Biological and medical sciences; endometrial carcinoma; Endometrial Neoplasms - chemistry; Endometrial Neoplasms - mortality; Endometrial Neoplasms - pathology; Female; Female genital diseases; Gynecology. Andrology. Obstetrics; Humans; Immunohistochemistry; Ki-67 Antigen - analysis; Ki-67 Antigen - immunology; Medical sciences; MIB-1; Multivariate Analysis; Neoplasm Staging; Prognosis; proliferation index; survival; Tumors
• ISSN: 0090-8258; 1095-6859
• DOI: 10.1006/gyno.1999.5615

Objective. MIB-1, a monoclonal antibody to the Ki-67 antigen, has presumptively been shown to be predictive of recurrent disease in patients with endometrial cancer. In order to more conclusively establish whether MIB-1 staining can be used as a prognostic indicator of recurrent disease or survival, a larger group of patients with a minimum follow-up of 5 years was analyzed. Methods. The tumors from 147 consecutive patients receiving primary surgical therapy for endometrial carcinoma were evaluated with the MIB-1 monoclonal antibody. Proliferation index was quantified by image analysis. Patients were followed for a minimum of 60 months. In addition to MIB-1 staining, histologic type, stage, grade, depth of invasion, lymphovascular space invasion, and peritoneal cytology were evaluated as prognostic indicators. Results. Twenty-five of 147 patients died during the study period. MIB-1 staining was not significantly elevated in advanced (stage II, III, and IV) as opposed to early (stage I) carcinomas (P = 0.38). In patients whose tumor MIB-1 staining was less than 33.0%, no deaths occurred. By multivariate analysis, only MIB-1 staining (P < 0.001), FIGO stage (P = 0.005), and LVI (P = 0.005) were shown to be independent prognostic indicators predictive of survival. Conclusion. In this series of 147 consecutive patients with endometrial carcinoma, the monoclonal antibody MIB-1 was shown to be an independent prognostic indicator of 5-year survival. This follow-up further validates the previous work regarding the significance and potential usefulness of MIB-1 as a prognostic indicator.