Systematic search for susceptibility genes in different populations

We analyzed the first replicate of each of the four simulated population samples from three distinct populations by linkage and association genome scans and could identify three regions with susceptibility loci for the disease: on chromosome 1, marker D1G024, with strong evidence for gene×environmen...

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Bibliographic Details
Published in:Genetic epidemiology 1999, Vol.17 (S1), p.S709-S714
Main Authors: Schmidt, Silke, Scholz, Michael, Loesgen, Sabine, Bickeböller, Heike
Format: Article
Language:English
Subjects:
Alleles
association
Environment
Genetic Linkage
Genetic Markers
Genetic Predisposition to Disease
Genetic Testing
gene×environment interaction
Genome
genome scan
Humans
linkage
Penetrance
Reproducibility of Results
Software
Statistics, Nonparametric
Citations: Items that this one cites
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Summary:We analyzed the first replicate of each of the four simulated population samples from three distinct populations by linkage and association genome scans and could identify three regions with susceptibility loci for the disease: on chromosome 1, marker D1G024, with strong evidence for gene×environment interaction; on chromosome 3, around marker D3G045; and on chromosome 5, markers D5G035–D5G042. Our results were obtained without knowing the true disease model and are compared with this model in the discussion.
ISSN:0741-0395
1098-2272
DOI:10.1002/gepi.13701707116