Discovery of a New Class of Inhibitors of Mycobacterium tuberculosis Protein Tyrosine Phosphatase B by Biology-Oriented Synthesis

A biologically relevant collection: The synthesis of a macroline‐derived compound collection (see general structural formula) on the basis of the criterion of biological relevance yielded an unprecedented class of inhibitors of the title mycobacterial enzyme, which is a potential target for the deve...

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Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2008-07, Vol.47 (32), p.5973-5977
Main Authors: Nören-Müller, Andrea, Wilk, Wolfram, Saxena, Krishna, Schwalbe, Harald, Kaiser, Markus, Waldmann, Herbert
Format: Article
Language:English
Subjects:
biology-oriented synthesis
chemical biology
enzyme inhibitors
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - pharmacology
Indoles - chemical synthesis
Indoles - chemistry
Indoles - pharmacology
Microbial Sensitivity Tests
Mycobacterium tuberculosis - drug effects
Mycobacterium tuberculosis - enzymology
natural products
phosphatases
Protein Tyrosine Phosphatases - antagonists & inhibitors
Structure-Activity Relationship
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Summary:A biologically relevant collection: The synthesis of a macroline‐derived compound collection (see general structural formula) on the basis of the criterion of biological relevance yielded an unprecedented class of inhibitors of the title mycobacterial enzyme, which is a potential target for the development of new antimycobacterial drug candidates.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200801566