Two tests of association for a susceptibility locus for families of variable size: An example using two sampling strategies

A two‐stage approach was used to analyze Problem 2 simulated data from Genetic Analysis Workshop 11. In the first stage, we tested for linkage with the Haseman‐Elston test in SIBPAL. Markers that were significant in the first stage were followed up with two types of association tests. These associat...

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Bibliographic Details
Published in:Genetic epidemiology 1999, Vol.17 (S1), p.S655-S660
Main Authors: Monks, S.A., Martin, E.R., Umbach, D.M., Kaplan, N.L.
Format: Article
Language:English
Subjects:
Environment
Family
family based
Genetic Linkage
Genetic Markers
Genetic Predisposition to Disease
Genetic Testing
Humans
Linkage Disequilibrium
Models, Genetic
Monte Carlo Method
sibship
Software
transmission/disequilibrium
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Summary:A two‐stage approach was used to analyze Problem 2 simulated data from Genetic Analysis Workshop 11. In the first stage, we tested for linkage with the Haseman‐Elston test in SIBPAL. Markers that were significant in the first stage were followed up with two types of association tests. These association tests differ in the type of family information used: 1) parental transmissions to affected children or 2) differences in marker allele frequencies between affected and unaffected siblings. We also explored how the conclusions changed when different sampling strategies were used. Of particular interest was whether the entire data set should be used to test for both linkage and association or whether the data set should be halved to allow for replication of the initial association results.
ISSN:0741-0395
1098-2272
DOI:10.1002/gepi.13701707107