Glycolipid Markers of Astrocytomas and Oligodendrogliomas

Neutral glycolipids and gangliosides were analyzed in 149 astrocytomas (A), 46 oligodendrogliomas (O), and 21 oligoastrocytomas (OA) to determine if specific glycolipids correlate with histologic diagnosis and grade. Positivity for asialoGMl (GA1) and negativity for paragloboside by immuno-TLC corre...

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Bibliographic Details
Published in:Journal of neuropathology and experimental neurology 1999-12, Vol.58 (12), p.1250-1262
Main Authors: Yates, Allan J, Comas, Theodore, Scheithauer, Bernd W, Burger, Peter C, Pearl, Dennis K
Format: Article
Language:English
Subjects:
Adolescent
Adult
Astrocytoma
Astrocytoma - metabolism
Astrocytoma - pathology
Biological and medical sciences
Biological markers
Biomarkers, Tumor - metabolism
Brain Neoplasms - metabolism
Brain Neoplasms - pathology
Diagnosis
Female
Gangliosides - metabolism
Glycolipids
Glycolipids - metabolism
Humans
Male
Medical sciences
Middle Aged
Neurology
Oligodendroglioma
Oligodendroglioma - metabolism
Oligodendroglioma - pathology
Tumors of the nervous system. Phacomatoses
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Summary:Neutral glycolipids and gangliosides were analyzed in 149 astrocytomas (A), 46 oligodendrogliomas (O), and 21 oligoastrocytomas (OA) to determine if specific glycolipids correlate with histologic diagnosis and grade. Positivity for asialoGMl (GA1) and negativity for paragloboside by immuno-TLC correlated with histological diagnosis of O and OA, whereas the reverse pattern correlated with A. High levels (over 5 µg hexose per mg dry weight) of CMH generally correlated with an O component, but the association was not as strong as for either GA1 presence or paragloboside absence. Pilocytic astrocytomas and pleomorphic xanthoastrocytomas had high proportions (>15%) of globoside, low ratios (
ISSN:0022-3069
1554-6578
DOI:10.1097/00005072-199912000-00006