Absence of the deltaccr5 mutation in indigenous populations of the Brazilian Amazon

Carriers of the deltaccr5 allele, which contains a deletion of 32 bases in relation to the normal allele of the beta-chemokine receptor gene (CCR5), have increased resistance to HIV-1 infection. The higher frequency of this mutation in Europeans than in Blacks and Asians, has generated interest in d...

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Bibliographic Details
Published in:Human genetics 1999-11, Vol.105 (5), p.442-443
Main Authors: Leboute, A P, de Carvalho, M W, Simões, A L
Format: Article
Language:English
Subjects:
AIDS/HIV
Alleles
Brazil
Emigration and Immigration
Europe
European Continental Ancestry Group - genetics
Gene Frequency
HIV Infections - genetics
Homozygote
Humans
Indians, South American - genetics
Polymorphism, Genetic
Receptors, CCR5 - genetics
Sequence Deletion
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Summary:Carriers of the deltaccr5 allele, which contains a deletion of 32 bases in relation to the normal allele of the beta-chemokine receptor gene (CCR5), have increased resistance to HIV-1 infection. The higher frequency of this mutation in Europeans than in Blacks and Asians, has generated interest in determining its distribution in other populations. The population of this study involved 300 Amerindians from four Brazilian Amazon tribes (Tikuna, Baniwa, Kashinawa, and Kanamari). All of the individuals were homozygous for the normal allele, which corroborates the hypothesis that the deltaccr5 allele has a European origin, and that its occurrence in urban populations in South America is the result of immigration.
ISSN:0340-6717