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Serum levels of brain-derived neurotrophic factor in schizophrenia on a hypocaloric diet

Dietary factors influence BDNF in animal studies, but there is no comparable data in clinical populations. We examined the effect of a dietary intervention on BDNF serum levels in 67 DSM-IV schizophrenic outpatients (51 males and 16 females). Two groups were assessed in a cross-sectional study: one...

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Published in:Progress in neuro-psychopharmacology & biological psychiatry 2008-08, Vol.32 (6), p.1595-1598
Main Authors: Guimarães, Lísia Rejane, Jacka, Felice N., Gama, Clarissa Severino, Berk, Michael, Leitão-Azevedo, Carmen Lúcia, Belmonte de Abreu, Martha Guerra, Lobato, Maria Inês, Andreazza, Ana Cristina, Ceresér, Keila Maria, Kapczinski, Flávio, Belmonte-de-Abreu, Paulo
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Language:English
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Summary:Dietary factors influence BDNF in animal studies, but there is no comparable data in clinical populations. We examined the effect of a dietary intervention on BDNF serum levels in 67 DSM-IV schizophrenic outpatients (51 males and 16 females). Two groups were assessed in a cross-sectional study: one on a hypocaloric diet (HD) and the other not on a hypocaloric diet. Weight, height and BMI data were collected concurrently with 5-ml blood sampling of each subject. BDNF levels were measured with a sandwich-ELISA. The blood sample was obtained a minimum of one month after the exposure to dietary intervention. Serum BDNF levels were significantly higher in patients on the HD ( p = 0.023). Additional research examining the interaction among patterns of nutritional food behavior and underlying physiopathology may result in insights upon which evidence-based decisions regarding dietary interventions can be made in people identified with major psychiatric disorders, such as schizophrenia.
ISSN:0278-5846
1878-4216
DOI:10.1016/j.pnpbp.2008.06.004