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Serum levels of brain-derived neurotrophic factor in schizophrenia on a hypocaloric diet
Dietary factors influence BDNF in animal studies, but there is no comparable data in clinical populations. We examined the effect of a dietary intervention on BDNF serum levels in 67 DSM-IV schizophrenic outpatients (51 males and 16 females). Two groups were assessed in a cross-sectional study: one...
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| Published in: | Progress in neuro-psychopharmacology & biological psychiatry 2008-08, Vol.32 (6), p.1595-1598 |
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| cites | cdi_FETCH-LOGICAL-c418t-502b901e954e1f116fea300e7d74aa0ae9abfd8f7758e613fb3e16d1c182bf3d3 |
| container_end_page | 1598 |
| container_issue | 6 |
| container_start_page | 1595 |
| container_title | Progress in neuro-psychopharmacology & biological psychiatry |
| container_volume | 32 |
| creator | Guimarães, Lísia Rejane Jacka, Felice N. Gama, Clarissa Severino Berk, Michael Leitão-Azevedo, Carmen Lúcia Belmonte de Abreu, Martha Guerra Lobato, Maria Inês Andreazza, Ana Cristina Ceresér, Keila Maria Kapczinski, Flávio Belmonte-de-Abreu, Paulo |
| description | Dietary factors influence BDNF in animal studies, but there is no comparable data in clinical populations. We examined the effect of a dietary intervention on BDNF serum levels in 67 DSM-IV schizophrenic outpatients (51 males and 16 females). Two groups were assessed in a cross-sectional study: one on a hypocaloric diet (HD) and the other not on a hypocaloric diet. Weight, height and BMI data were collected concurrently with 5-ml blood sampling of each subject. BDNF levels were measured with a sandwich-ELISA. The blood sample was obtained a minimum of one month after the exposure to dietary intervention. Serum BDNF levels were significantly higher in patients on the HD (
p
=
0.023). Additional research examining the interaction among patterns of nutritional food behavior and underlying physiopathology may result in insights upon which evidence-based decisions regarding dietary interventions can be made in people identified with major psychiatric disorders, such as schizophrenia. |
| doi_str_mv | 10.1016/j.pnpbp.2008.06.004 |
| format | article |
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p
=
0.023). Additional research examining the interaction among patterns of nutritional food behavior and underlying physiopathology may result in insights upon which evidence-based decisions regarding dietary interventions can be made in people identified with major psychiatric disorders, such as schizophrenia.</description><identifier>ISSN: 0278-5846</identifier><identifier>EISSN: 1878-4216</identifier><identifier>DOI: 10.1016/j.pnpbp.2008.06.004</identifier><identifier>PMID: 18582525</identifier><identifier>CODEN: PNPPD7</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adult ; Adult and adolescent clinical studies ; BDNF ; Biological and medical sciences ; BMI ; Body Mass Index ; Body Weight - physiology ; Brain-Derived Neurotrophic Factor - blood ; Caloric Restriction - psychology ; Cross-Sectional Studies ; Eating - psychology ; Feeding Behavior - physiology ; Female ; Humans ; Hypocaloric diet ; Male ; Medical sciences ; Neuropharmacology ; Neurotrophins ; Pharmacology. Drug treatments ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Regression Analysis ; Schizophrenia ; Schizophrenia - blood ; Schizophrenic Psychology</subject><ispartof>Progress in neuro-psychopharmacology & biological psychiatry, 2008-08, Vol.32 (6), p.1595-1598</ispartof><rights>2008 Elsevier Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-502b901e954e1f116fea300e7d74aa0ae9abfd8f7758e613fb3e16d1c182bf3d3</citedby><cites>FETCH-LOGICAL-c418t-502b901e954e1f116fea300e7d74aa0ae9abfd8f7758e613fb3e16d1c182bf3d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20593095$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18582525$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guimarães, Lísia Rejane</creatorcontrib><creatorcontrib>Jacka, Felice N.</creatorcontrib><creatorcontrib>Gama, Clarissa Severino</creatorcontrib><creatorcontrib>Berk, Michael</creatorcontrib><creatorcontrib>Leitão-Azevedo, Carmen Lúcia</creatorcontrib><creatorcontrib>Belmonte de Abreu, Martha Guerra</creatorcontrib><creatorcontrib>Lobato, Maria Inês</creatorcontrib><creatorcontrib>Andreazza, Ana Cristina</creatorcontrib><creatorcontrib>Ceresér, Keila Maria</creatorcontrib><creatorcontrib>Kapczinski, Flávio</creatorcontrib><creatorcontrib>Belmonte-de-Abreu, Paulo</creatorcontrib><title>Serum levels of brain-derived neurotrophic factor in schizophrenia on a hypocaloric diet</title><title>Progress in neuro-psychopharmacology & biological psychiatry</title><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><description>Dietary factors influence BDNF in animal studies, but there is no comparable data in clinical populations. We examined the effect of a dietary intervention on BDNF serum levels in 67 DSM-IV schizophrenic outpatients (51 males and 16 females). Two groups were assessed in a cross-sectional study: one on a hypocaloric diet (HD) and the other not on a hypocaloric diet. Weight, height and BMI data were collected concurrently with 5-ml blood sampling of each subject. BDNF levels were measured with a sandwich-ELISA. The blood sample was obtained a minimum of one month after the exposure to dietary intervention. Serum BDNF levels were significantly higher in patients on the HD (
p
=
0.023). Additional research examining the interaction among patterns of nutritional food behavior and underlying physiopathology may result in insights upon which evidence-based decisions regarding dietary interventions can be made in people identified with major psychiatric disorders, such as schizophrenia.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>BDNF</subject><subject>Biological and medical sciences</subject><subject>BMI</subject><subject>Body Mass Index</subject><subject>Body Weight - physiology</subject><subject>Brain-Derived Neurotrophic Factor - blood</subject><subject>Caloric Restriction - psychology</subject><subject>Cross-Sectional Studies</subject><subject>Eating - psychology</subject><subject>Feeding Behavior - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Hypocaloric diet</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Neurotrophins</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Regression Analysis</subject><subject>Schizophrenia</subject><subject>Schizophrenia - blood</subject><subject>Schizophrenic Psychology</subject><issn>0278-5846</issn><issn>1878-4216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqFkcGKFDEQhoMo7uzqEwiSi966rSSddPrgQRZdhYU9uAveQjqpMBl6Om3SPbD79PY4g970VEXx_UXxFSFvGNQMmPqwq6dx6qeaA-gaVA3QPCMbpltdNZyp52QDfO2lbtQFuSxlBwBMgHhJLpiWmksuN-THd8zLng54wKHQFGifbRwrjzke0NMRl5zmnKZtdDRYN6dM40iL28andZhxjJamkVq6fZySs0PKK-gjzq_Ii2CHgq_P9Yo8fPl8f_21ur27-Xb96bZyDdNzJYH3HTDsZIMsMKYCWgGArW8ba8FiZ_vgdWhbqVExEXqBTHnmmOZ9EF5ckfenvVNOPxcss9nH4nAY7IhpKUZ1QjXA-X9BDlxKqfUKihPociolYzBTjnubHw0DczRvdua3eXM0b0CZ1fyaentev_R79H8zZ9Ur8O4M2LKKCtmOLpY_HAfZCeiO3McTtz4EDxGzKS7i6NDHjG42PsV_HvILVgWjoQ</recordid><startdate>20080801</startdate><enddate>20080801</enddate><creator>Guimarães, Lísia Rejane</creator><creator>Jacka, Felice N.</creator><creator>Gama, Clarissa Severino</creator><creator>Berk, Michael</creator><creator>Leitão-Azevedo, Carmen Lúcia</creator><creator>Belmonte de Abreu, Martha Guerra</creator><creator>Lobato, Maria Inês</creator><creator>Andreazza, Ana Cristina</creator><creator>Ceresér, Keila Maria</creator><creator>Kapczinski, Flávio</creator><creator>Belmonte-de-Abreu, Paulo</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20080801</creationdate><title>Serum levels of brain-derived neurotrophic factor in schizophrenia on a hypocaloric diet</title><author>Guimarães, Lísia Rejane ; Jacka, Felice N. ; Gama, Clarissa Severino ; Berk, Michael ; Leitão-Azevedo, Carmen Lúcia ; Belmonte de Abreu, Martha Guerra ; Lobato, Maria Inês ; Andreazza, Ana Cristina ; Ceresér, Keila Maria ; Kapczinski, Flávio ; Belmonte-de-Abreu, Paulo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-502b901e954e1f116fea300e7d74aa0ae9abfd8f7758e613fb3e16d1c182bf3d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>BDNF</topic><topic>Biological and medical sciences</topic><topic>BMI</topic><topic>Body Mass Index</topic><topic>Body Weight - physiology</topic><topic>Brain-Derived Neurotrophic Factor - blood</topic><topic>Caloric Restriction - psychology</topic><topic>Cross-Sectional Studies</topic><topic>Eating - psychology</topic><topic>Feeding Behavior - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Hypocaloric diet</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Neurotrophins</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Regression Analysis</topic><topic>Schizophrenia</topic><topic>Schizophrenia - blood</topic><topic>Schizophrenic Psychology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guimarães, Lísia Rejane</creatorcontrib><creatorcontrib>Jacka, Felice N.</creatorcontrib><creatorcontrib>Gama, Clarissa Severino</creatorcontrib><creatorcontrib>Berk, Michael</creatorcontrib><creatorcontrib>Leitão-Azevedo, Carmen Lúcia</creatorcontrib><creatorcontrib>Belmonte de Abreu, Martha Guerra</creatorcontrib><creatorcontrib>Lobato, Maria Inês</creatorcontrib><creatorcontrib>Andreazza, Ana Cristina</creatorcontrib><creatorcontrib>Ceresér, Keila Maria</creatorcontrib><creatorcontrib>Kapczinski, Flávio</creatorcontrib><creatorcontrib>Belmonte-de-Abreu, Paulo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guimarães, Lísia Rejane</au><au>Jacka, Felice N.</au><au>Gama, Clarissa Severino</au><au>Berk, Michael</au><au>Leitão-Azevedo, Carmen Lúcia</au><au>Belmonte de Abreu, Martha Guerra</au><au>Lobato, Maria Inês</au><au>Andreazza, Ana Cristina</au><au>Ceresér, Keila Maria</au><au>Kapczinski, Flávio</au><au>Belmonte-de-Abreu, Paulo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum levels of brain-derived neurotrophic factor in schizophrenia on a hypocaloric diet</atitle><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><date>2008-08-01</date><risdate>2008</risdate><volume>32</volume><issue>6</issue><spage>1595</spage><epage>1598</epage><pages>1595-1598</pages><issn>0278-5846</issn><eissn>1878-4216</eissn><coden>PNPPD7</coden><abstract>Dietary factors influence BDNF in animal studies, but there is no comparable data in clinical populations. We examined the effect of a dietary intervention on BDNF serum levels in 67 DSM-IV schizophrenic outpatients (51 males and 16 females). Two groups were assessed in a cross-sectional study: one on a hypocaloric diet (HD) and the other not on a hypocaloric diet. Weight, height and BMI data were collected concurrently with 5-ml blood sampling of each subject. BDNF levels were measured with a sandwich-ELISA. The blood sample was obtained a minimum of one month after the exposure to dietary intervention. Serum BDNF levels were significantly higher in patients on the HD (
p
=
0.023). Additional research examining the interaction among patterns of nutritional food behavior and underlying physiopathology may result in insights upon which evidence-based decisions regarding dietary interventions can be made in people identified with major psychiatric disorders, such as schizophrenia.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>18582525</pmid><doi>10.1016/j.pnpbp.2008.06.004</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0278-5846 |
| ispartof | Progress in neuro-psychopharmacology & biological psychiatry, 2008-08, Vol.32 (6), p.1595-1598 |
| issn | 0278-5846 1878-4216 |
| language | eng |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Adult Adult and adolescent clinical studies BDNF Biological and medical sciences BMI Body Mass Index Body Weight - physiology Brain-Derived Neurotrophic Factor - blood Caloric Restriction - psychology Cross-Sectional Studies Eating - psychology Feeding Behavior - physiology Female Humans Hypocaloric diet Male Medical sciences Neuropharmacology Neurotrophins Pharmacology. Drug treatments Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Regression Analysis Schizophrenia Schizophrenia - blood Schizophrenic Psychology |
| title | Serum levels of brain-derived neurotrophic factor in schizophrenia on a hypocaloric diet |
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