In vitro infectivity of species of Leishmania (Viannia) responsible for American cutaneous leishmaniasis

There is little available information regarding the infectivity of New World Leishmania species, particularly those from the Amazonian Brazil, where there are six species of the subgenus Viannia causing American cutaneous leishmaniasis (ACL). The aim of this study was to compare, in vitro, the poten...

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Bibliographic Details
Published in:Parasitology research (1987) 2008-09, Vol.103 (4), p.771-776
Main Authors: Campos, Marliane Batista, De Castro Gomes, Cláudia Maria, de Souza, Adelson Alcimar Almeida, Lainson, Ralph, Corbett, Carlos Eduardo Pereira, Silveira, Fernando Tobias
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Cells, Cultured
Culture Media - chemistry
Female
Fundamental and applied biological sciences. Psychology
General aspects
General aspects and techniques. Study of several systematic groups. Models
Humans
Immunology
Invertebrates
Leishmania - immunology
Leishmania - isolation & purification
Leishmania - pathogenicity
Leishmaniasis, Cutaneous - immunology
Leishmaniasis, Cutaneous - parasitology
Macrophages, Peritoneal - immunology
Macrophages, Peritoneal - parasitology
Male
Medical Microbiology
Mice
Mice, Inbred BALB C
Microbiology
Nitric Oxide - biosynthesis
Original Paper
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Summary:There is little available information regarding the infectivity of New World Leishmania species, particularly those from the Amazonian Brazil, where there are six species of the subgenus Viannia causing American cutaneous leishmaniasis (ACL). The aim of this study was to compare, in vitro, the potential infectivity of the following Leishmania (Viannia) spp.: L. (V.) braziliensis from localized cutaneous leishmaniasis (LCL) and mucocutaneous leishmaniasis (MCL) patients, L. (V.) guyanensis, L. (V.) shawi, L. (V.) lainsoni and L. (V.) naiffi from LCL patients only, in cultured BALB/c mice peritoneal macrophage, as well as the production of NO by the infected cells. The infectivity of parasites was expressed by the infection index and, the nitric oxide (NO) production in the macrophage culture supernatant was measured by the Griess method. It was found that L. (V.) braziliensis from MCL, the more severe form of disease, showed the highest (p
ISSN:0932-0113
1432-1955
DOI:10.1007/s00436-008-1039-8