Clinical outcomes and risk factors of community-acquired pneumonia caused by gram-negative bacilli

To identify specific risk factors and clinical outcomes of community-acquired pneumonia (CAP) caused by gram-negative bacilli (GNB), we compared the clinical features and outcomes of patients with CAP due to GNB with those of patients with non-GNB pneumonia. We performed a prospective observational...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 2008-08, Vol.27 (8), p.657-661
Main Authors: Kang, C.-I., Song, J.-H., Oh, W. S., Ko, K. S., Chung, D. R., Peck, K. R.
Format: Article
Language:English
Subjects:
Acinetobacter baumannii
Adult
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antimicrobial agents
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Cardiovascular diseases
Clinical outcomes
Community-Acquired Infections - drug therapy
Community-Acquired Infections - epidemiology
Community-Acquired Infections - microbiology
Community-Acquired Infections - mortality
Data processing
Drug Resistance, Bacterial
Dyspnea
Enterobacter
Etiology
Gram-negative bacilli
Gram-Negative Bacteria - drug effects
Humans
Hyponatremia
Infectious diseases
Internal Medicine
Klebsiella pneumoniae
Malignancy
Medical Microbiology
Medical sciences
Microorganisms
Mortality
Multivariate analysis
Nursing
Observational studies
Pneumology
Pneumonia
Pneumonia - drug therapy
Pneumonia - epidemiology
Pneumonia - microbiology
Pneumonia - mortality
Pseudomonas aeruginosa
Respiration
Respiratory system : syndromes and miscellaneous diseases
Risk Factors
Septic shock
Serratia marcescens
Smoking
Treatment Outcome
Ventilation
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Summary:To identify specific risk factors and clinical outcomes of community-acquired pneumonia (CAP) caused by gram-negative bacilli (GNB), we compared the clinical features and outcomes of patients with CAP due to GNB with those of patients with non-GNB pneumonia. We performed a prospective observational study of 912 cases of adult CAP in Asian countries from January 2002 to December 2004. Systemic laboratory evaluation for determining the etiology and clinical evaluation were performed. Of 912 cases with CAP, 93 (10.1%) cases were caused by GNB: 59 with K. pneumoniae , 25 P. aeruginosa , 7 Enterobacter species, 1 Acinetobacter baumannii , and 1 Serratia marcescens . CAP caused by GNB was more frequently associated with septic shock, malignancy, cardiovascular diseases, smoking, hyponatremia, and dyspnea, according to multivariate analysis ( P  
ISSN:0934-9723
1435-4373
DOI:10.1007/s10096-008-0485-7