Factor H family proteins and human diseases

Complement is a major defense system of innate immunity and aimed to destroy microbes. One of the central complement regulators is factor H, which belongs to a protein family that includes CFHL1 and five factor H-related (CFHR) proteins. Recent evidence shows that factor H family proteins (factor H...

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Bibliographic Details
Published in:Immunology today (Amsterdam. Regular ed.) 2008-08, Vol.29 (8), p.380-387
Main Authors: Józsi, Mihály, Zipfel, Peter F
Format: Article
Language:English
Subjects:
Allergy and Immunology
Complement Activation - physiology
Complement Factor H - physiology
Disease
Genes
Glomerulonephritis, Membranoproliferative - genetics
Glomerulonephritis, Membranoproliferative - immunology
Hemolytic-Uremic Syndrome - genetics
Hemolytic-Uremic Syndrome - immunology
Humans
Infection - etiology
Ligands
Lipoproteins
Macular Degeneration - genetics
Macular Degeneration - immunology
Proteins
Target recognition
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Summary:Complement is a major defense system of innate immunity and aimed to destroy microbes. One of the central complement regulators is factor H, which belongs to a protein family that includes CFHL1 and five factor H-related (CFHR) proteins. Recent evidence shows that factor H family proteins (factor H and CFHRs) are associated with diverse and severe human diseases and are also used by human pathogenic microbes for complement evasion. Therefore, dissecting the exact functions of the individual CFHR proteins will provide insights into the pathophysiology of such inflammatory and infectious diseases and will define the therapeutic potential of these proteins.
ISSN:1471-4906
0167-5699
1471-4981
DOI:10.1016/j.it.2008.04.008