Amelioration of radiation-induced liver damage in partially hepatectomized rats by hepatocyte transplantation

Hepatic tumors often recur in the liver after surgical resection. Postoperative radiotherapy (RT) could improve survival, but curative RT may induce delayed life-threatening radiation-induced liver damage. Because RT inhibits liver regeneration, we hypothesized that unirradiated, transplanted hepato...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1999-12, Vol.59 (23), p.5871-5874
Main Authors: GUHA, C, SHARMA, A, ROY-CHOWDHURY, J, GUPTA, S, ALFIERI, A, GORLA, G. R, GAGANDEEP, S, SOKHI, R, ROY-CHOWDHURY, N, TANAKA, K. E, VIKRAM, B
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell Transplantation
Diseases of the digestive system
Hepatectomy
Liver - cytology
Liver - pathology
Liver - radiation effects
Liver Regeneration
Male
Medical sciences
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Rats
Rats, Inbred F344
Spleen
Transplantation, Heterologous
Transplantation, Isogeneic
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Summary:Hepatic tumors often recur in the liver after surgical resection. Postoperative radiotherapy (RT) could improve survival, but curative RT may induce delayed life-threatening radiation-induced liver damage. Because RT inhibits liver regeneration, we hypothesized that unirradiated, transplanted hepatocytes would proliferate preferentially in a partially resected and irradiated liver, providing metabolic support. We subjected F344 rats to hepatic RT and partial hepatectomy with/without a single intrasplenic, syngeneic hepatocyte transplantation. Hepatocyte transplantation ameliorated radiation-induced liver damage and improved survival of rats receiving RT after partial hepatectomy. We further demonstrated that transplanted hepatocytes extensively repopulate and function in a heavily irradiated rat liver.
ISSN:0008-5472
1538-7445