Improved Reflux Monitoring in the Acute Gastroesophageal Reflux Porcine Model Using Esophageal Multichannel Intraluminal Impedance Measurement

• Published in: Journal of gastrointestinal surgery 2008-08, Vol.12 (8), p.1351-1358
• Main Authors: Müller-Stich, Beat Peter, Mehrabi, Arianeb, Kenngott, Hannes Götz, Mood, Zhoobin, Funouni, Hamidreza, Reiter, Michael Andreas, Linke, Georg Richard, Hinz, Ulf, Gutt, Carsten Nils, Köninger, Jörg
• Format: Article
• Language: English
• Subjects: Animals; Digestive system; Disease Models, Animal; Electric Impedance; Esophagus - physiopathology; Gastroenterology; Gastroesophageal Reflux - diagnosis; Gastroesophageal Reflux - physiopathology; Gastrointestinal diseases; Manometry; Medicine; Medicine & Public Health; Monitoring, Physiologic - instrumentation; Muscle, Smooth - physiopathology; Original Article; Pressure; Severity of Illness Index; Surgery; Swine; Throat
• ISSN: 1091-255X; 1873-4626
• DOI: 10.1007/s11605-008-0547-2

Background Acute animal models are needed to obtain further insights into the mechanism of gastroesophageal reflux disease. Existing acute models use imprecise methods to detect reflux. The aim of the present study was to evaluate the potential of esophageal multichannel intraluminal impedance measurement (MII) to improve the quality of results of acute reflux porcine models. Materials and Methods MII was used in ten pigs to monitor gastroesophageal reflux. Measurements were obtained (A) before and (B) after mobilization of the esophagus and (C) after myotomy. The results were compared to those obtained when reflux was monitored by esophageal drainage of intragastrically infused blue solution (DBS). Results The times to first appearance of reflux were 67% (A), 86% (B), and 57% (C) of those by DBS when detected by MII; p