MHC superfamily structure and the immune system

During the past year, a plethora of structural information has provided detailed insights into the interactions between classical MHC class I molecules and their cognate receptors on T cells. Likewise, there have been major advances in our knowledge of the structures and functions of five nonclassic...

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Bibliographic Details
Published in:Current Opinion in Structural Biology 1999-12, Vol.9 (6), p.745-753
Main Authors: Maenaka, Katsumi, Jones, E Yvonne
Format: Article
Language:English
Subjects:
Animals
Classical MHC class 1 and class 2
histocompatibility antigen H-2
histocompatibility antigen HLA
Humans
Immune System - chemistry
Immune System - immunology
Killer Cells, Natural - immunology
Major histocompatability complex (MHC) molecule
Major Histocompatibility Complex - immunology
Mice
Models, Molecular
Natural killer cell
Nonclassical MHC-like molecules
Receptors, Antigen, T-Cell - immunology
T-cell receptor recognition
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Summary:During the past year, a plethora of structural information has provided detailed insights into the interactions between classical MHC class I molecules and their cognate receptors on T cells. Likewise, there have been major advances in our knowledge of the structures and functions of five nonclassical MHC-like molecules: HLA-DM (murine H2-M), HLA-E, HFE, ZAG and MIC-A.
ISSN:0959-440X
1879-033X
DOI:10.1016/S0959-440X(99)00039-1