Tight junctions: Closing in on the seal

The claudins have recently been identified as a large family of transmembrane proteins located at tight junctions between epithelial cells; they create the paracellular diffusion barrier and, surprisingly, may also confer channel-like selectivity for passage of solutes through the tissue barrier.

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Bibliographic Details
Published in:Current biology 1999-12, Vol.9 (24), p.R922-R924
Main Authors: Anderson, James Melvin, Van Itallie, Christina M.
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biological Transport, Active
Cell Biology
claudin
Epithelial Cells - metabolism
Humans
Membrane Proteins - genetics
Membrane Proteins - metabolism
Occludin
Tight Junctions - metabolism
Tight Junctions - ultrastructure
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Description
Summary:The claudins have recently been identified as a large family of transmembrane proteins located at tight junctions between epithelial cells; they create the paracellular diffusion barrier and, surprisingly, may also confer channel-like selectivity for passage of solutes through the tissue barrier.
ISSN:0960-9822
1879-0445
DOI:10.1016/S0960-9822(00)80105-0