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Specific calcitonin gene-related peptide binding sites present throughout rat intestine
Calcitonin gene-related peptide is found extensively in the innervation of the intestine and has potent pharmacological effects on secretion, blood flow, and motility. Although essential for assessing the physiological significance of CGRP, detailed information concerning the distribution of its rec...
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Published in: | Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1999-11, Vol.20 (11), p.1361-1366 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Calcitonin gene-related peptide is found extensively in the innervation of the intestine and has potent pharmacological effects on secretion, blood flow, and motility. Although essential for assessing the physiological significance of CGRP, detailed information concerning the distribution of its receptor(s) within the intestine is lacking. By using autoradiographic methods, we identified specific binding sites for
125I-tyr
0-CGRP-α in all regions of the rat small and large intestine. Particularly dense saturatable binding is observed within the lamina propria. There is moderate saturatible binding in the myenteric plexuses. These findings clearly support the notion that CGRP has a neuroeffector role in intestinal functions. |
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ISSN: | 0196-9781 1873-5169 |
DOI: | 10.1016/S0196-9781(99)00142-4 |