Loading…

Specific calcitonin gene-related peptide binding sites present throughout rat intestine

Calcitonin gene-related peptide is found extensively in the innervation of the intestine and has potent pharmacological effects on secretion, blood flow, and motility. Although essential for assessing the physiological significance of CGRP, detailed information concerning the distribution of its rec...

Full description

Saved in:
Bibliographic Details
Published in:Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1999-11, Vol.20 (11), p.1361-1366
Main Authors: Özdemir, F.-A, Berghöfer, P, Göke, R, Göke, B, McGregor, G.P
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Calcitonin gene-related peptide is found extensively in the innervation of the intestine and has potent pharmacological effects on secretion, blood flow, and motility. Although essential for assessing the physiological significance of CGRP, detailed information concerning the distribution of its receptor(s) within the intestine is lacking. By using autoradiographic methods, we identified specific binding sites for 125I-tyr 0-CGRP-α in all regions of the rat small and large intestine. Particularly dense saturatable binding is observed within the lamina propria. There is moderate saturatible binding in the myenteric plexuses. These findings clearly support the notion that CGRP has a neuroeffector role in intestinal functions.
ISSN:0196-9781
1873-5169
DOI:10.1016/S0196-9781(99)00142-4