Interleukin-6 and procalcitonin in children with sepsis and septic shock

Objectives. To examine the behavior of interleukin-6 (IL-6) and procalcitonin (PCT) and verify whether they can be used to differentiate children with septic conditions. Methods. Septic children aged between 28 days and 14 years, prospectively enrolled from 01/2004 to 12/2005, were divided into seps...

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Published in:Cytokine (Philadelphia, Pa.) Pa.), 2008-08, Vol.43 (2), p.160-164
Main Authors: Fioretto, José R., Martin, Joelma G., Kurokawa, Cilmery S., Carpi, Mário F., Bonatto, Rossano C., Ricchetti, Sandra M.Q., de Moraes, Marcos A., Padovani, Carlos R.
Format: Article
Language:English
Subjects:
Adolescent
Calcitonin - blood
Calcitonin Gene-Related Peptide
Child
Child, Preschool
Children
Female
Humans
Infant
Infant, Newborn
Interleukin-6
Interleukin-6 - blood
Male
Procalcitonin
Protein Precursors - blood
Sepsis
Sepsis - blood
Sepsis - pathology
Septic shock
Time Factors
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Summary:Objectives. To examine the behavior of interleukin-6 (IL-6) and procalcitonin (PCT) and verify whether they can be used to differentiate children with septic conditions. Methods. Septic children aged between 28 days and 14 years, prospectively enrolled from 01/2004 to 12/2005, were divided into sepsis (SG; n=47) and septic shock (SSG; n=43) groups. IL-6 and PCT were measured at admission (T0) and 12h later (T12h). PCT results were classed as: 0.5ng/mL=sepsis unlikely; ⩾0.5 to
ISSN:1043-4666
1096-0023
DOI:10.1016/j.cyto.2008.05.005