Transient diabetes insipidus following Escherichia coli meningitis complicated by ventriculoperitoneal shunt

Although disorders of ADH secretion associated with meningitis are usually consistent with the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH), central diabetes insipidus (DI) is an exceptional complication of meningitis. Transient DI as a complication of Escherichia coli (E. coli)...

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Bibliographic Details
Published in:Journal of endocrinological investigation 1999-11, Vol.22 (10), p.800-802
Main Authors: KABAKUS, N, YILMAZ, B, AYDINOGLU, H, SERHATHOGLU, S
Format: Article
Language:English
Subjects:
Bacterial diseases
Bacterial diseases of the nervous system. Bacterial myositis
Biological and medical sciences
Dandy-Walker Syndrome - complications
Dandy-Walker Syndrome - diagnosis
Deamino Arginine Vasopressin - therapeutic use
Diabetes Insipidus - etiology
Escherichia coli Infections - complications
Human bacterial diseases
Humans
Infant
Infectious diseases
Male
Medical sciences
Meningitis, Bacterial - complications
Polyuria - complications
Radioimmunoassay
Renal Agents - therapeutic use
Tomography, X-Ray Computed
Vasopressins - blood
Ventriculoperitoneal Shunt
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Summary:Although disorders of ADH secretion associated with meningitis are usually consistent with the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH), central diabetes insipidus (DI) is an exceptional complication of meningitis. Transient DI as a complication of Escherichia coli (E. coli) meningitis due to ventriculoperitoneal shunt in an 18-month-old boy is presented. Blood and spinal fluid cultures yielded E. coli, sensitive to cefotaxime. The DI arose on the day 3 after admission and continued to the day 20. Treatment comprised cefotaxime, dexamethasone, fluid adjustment and vasopressin. The course of our case supports that in cases of bacterial meningitis, initial fluid restriction may occasionally result in dangerous conditions. Therefore, all children with bacterial meningitis should be followed closely not only in terms of SIADH but also DI. To our knowledge this is the first transient DI associated with E. coli-caused meningitis case reported.
ISSN:0391-4097
1720-8386
DOI:10.1007/BF03343647