Application of the SeDeM Diagram and a new mathematical equation in the design of direct compression tablet formulation

Application of the new SeDeM Method is proposed for the study of the galenic properties of excipients in terms of the applicability of direct-compression technology. Through experimental studies of the parameters of the SeDeM Method and their subsequent mathematical treatment and graphical expressio...

Full description

Saved in:
Bibliographic Details
Published in:European journal of pharmaceutics and biopharmaceutics 2008-08, Vol.69 (3), p.1029-1039
Main Authors: Suñé-Negre, Josep M., Pérez-Lozano, Pilar, Miñarro, Montserrat, Roig, Manel, Fuster, Roser, Hernández, Carmen, Ruhí, Ramon, García-Montoya, Encarna, Ticó, Josep R.
Format: Article
Language:English
Subjects:
Algorithms
Angle of Repose ( α)
Biological and medical sciences
Bulk Density (Da)
Chemistry, Pharmaceutical - statistics & numerical data
Direct compression (DC)
Drug Compounding - statistics & numerical data
Drug Stability
Excipients
Expert system
Flowability ( t′′)
Formulation
General pharmacology
In Vitro Techniques
Inter-particle Porosity (Ie)
Lubrication
Medical sciences
Particle Size
Particle Size (%Pf)
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Powders
SeDeM
Tablets
Tapped Density (Dc)
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Application of the new SeDeM Method is proposed for the study of the galenic properties of excipients in terms of the applicability of direct-compression technology. Through experimental studies of the parameters of the SeDeM Method and their subsequent mathematical treatment and graphical expression (SeDeM Diagram), six different DC diluents were analysed to determine whether they were suitable for direct compression (DC). Based on the properties of these diluents, a mathematical equation was established to identify the best DC diluent and the optimum amount to be used when defining a suitable formula for direct compression, depending on the SeDeM properties of the active pharmaceutical ingredient (API) to be used. The results obtained confirm that the SeDeM Method is an appropriate system, effective tool for determining a viable formulation for tablets prepared by direct compression, and can thus be used as the basis for the relevant pharmaceutical development.
ISSN:0939-6411
1873-3441
DOI:10.1016/j.ejpb.2008.01.020