Pathogenicity of microbes associated with cystic fibrosis

Cystic fibrosis patients are exceptionally prone to colonisation by a narrow spectrum of pathogenic bacteria. Since pulmonary infection presently, and for the foreseeable future, plays such a major role in CF lung disease, we review the microbes that are classically associated with CF and the virule...

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Bibliographic Details
Published in:Microbes and Infection 1999-10, Vol.1 (12), p.1005-1014
Main Authors: Hutchison, Michael L., Govan, John R.W.
Format: Article
Language:English
Subjects:
bacteria
Bacterial diseases
Bacterial Infections - microbiology
Bacterial sepsis
Biological and medical sciences
Burkholderia cepacia - isolation & purification
Burkholderia cepacia - pathogenicity
cystic fibrosis
Cystic Fibrosis - microbiology
Gram-Negative Bacteria - isolation & purification
Gram-Negative Bacteria - pathogenicity
Haemophilus influenzae - isolation & purification
Haemophilus influenzae - pathogenicity
Human bacterial diseases
Humans
infection
Infectious diseases
Medical sciences
Pseudomonas aeruginosa - isolation & purification
Pseudomonas aeruginosa - pathogenicity
Respiratory System - microbiology
Respiratory Tract Infections - microbiology
Staphylococcus aureus - pathogenicity
Virulence
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Summary:Cystic fibrosis patients are exceptionally prone to colonisation by a narrow spectrum of pathogenic bacteria. Since pulmonary infection presently, and for the foreseeable future, plays such a major role in CF lung disease, we review the microbes that are classically associated with CF and the virulence, inflammatory potential and resistance mechanisms which contribute to the reduction in life expectancy for colonised CF patients.
ISSN:1286-4579
1769-714X
DOI:10.1016/S1286-4579(99)80518-8