Pancreatic adenocarcinoma: analysis of the effect of various concentrations of contrast material

Purpose The aim of this study was to compare the efficacy of two contrast materials with moderate and high iodine concentrations for the depiction of pancreatic adenocarcinoma. Materials and methods A series of 107 patients with histologically proven pancreatic adenocarcinoma underwent helical compu...

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Bibliographic Details
Published in:Japanese journal of radiology 2008-07, Vol.26 (6), p.355-361
Main Authors: Fukukura, Yoshihiko, Hamada, Hiroyuki, Kamiyama, Takuro, Yoneyama, Tomohide, Takumi, Koji, Nakajo, Masayuki
Format: Article
Language:English
Subjects:
Adenocarcinoma - diagnostic imaging
Adult
Contrast Media - administration & dosage
Female
Humans
Imaging
Iopamidol - administration & dosage
Male
Medicine
Medicine & Public Health
Middle Aged
Nuclear Medicine
Original Article
Pancreatic Neoplasms - diagnostic imaging
Radiology
Radiotherapy
Tomography, X-Ray Computed
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Summary:Purpose The aim of this study was to compare the efficacy of two contrast materials with moderate and high iodine concentrations for the depiction of pancreatic adenocarcinoma. Materials and methods A series of 107 patients with histologically proven pancreatic adenocarcinoma underwent helical computed tomography. A fixed dose of 100 ml of iopamidol 300 (mg I/ml) was administered to 50 patients (group A) and iopamidol 370 (mg I/ml) to 57 patients (group B) at the same injection rate (3 ml/s). Unenhanced helical scans and contrast-enhanced scans for three phases (30, 70, and 300 s after starting the infusion of contrast material) were obtained. We evaluated enhancement of the aorta, portal vein, hepatic parenchyma, pancreatic parenchyma, and pancreatic adenocarcinoma during each phase. Results During all phases, both aortic and pancreatic enhancement were significantly greater in group B than in group A ( P < 0.01). Enhancement of the portal vein and hepatic parenchyma was significantly greater at 70 and 300 s in group B than in group A (both P < 0.01). Tumor-to-pancreas contrast was significantly greater in group B than in group A at both 30 s ( P < 0.01) and 70 s ( P < 0.05). Conclusion Administration of contrast material with a high iodine concentration is more effective for depicting pancreatic adenocarcinomas.
ISSN:0288-2043
1867-1071
1862-5274
1867-108X
DOI:10.1007/s11604-008-0240-0