Acute effects of paroxetine on genioglossus activity in obstructive sleep apnea

To determine the acute effects of paroxetine on genioglossus activity during NREM sleep. A single dose of Paroxetine (40 mg) or placebo was administered four hours before bedtime on nights separated by one week in a double blind randomized crossover manner. The moving time average of genioglossus mu...

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Bibliographic Details
Published in:Sleep (New York, N.Y.) N.Y.), 1999-12, Vol.22 (8), p.1087-1092
Main Authors: BERRY, R. B, YAMAURA, E. M, GILL, K, REIST, C
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Cross-Over Studies
Dose-Response Relationship, Drug
Double-Blind Method
Electromyography
Female
Humans
Male
Medical sciences
Middle Aged
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
Paroxetine - pharmacology
Paroxetine - therapeutic use
Pharmacology. Drug treatments
Serotonin Uptake Inhibitors - pharmacology
Serotonin Uptake Inhibitors - therapeutic use
Serotoninergic system
Severity of Illness Index
Sleep Apnea, Obstructive - drug therapy
Sleep, REM - physiology
Tongue - drug effects
Tongue - innervation
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Summary:To determine the acute effects of paroxetine on genioglossus activity during NREM sleep. A single dose of Paroxetine (40 mg) or placebo was administered four hours before bedtime on nights separated by one week in a double blind randomized crossover manner. The moving time average of genioglossus muscle activity (EMGgg) expressed as a percentage of maximum was measured using a mouthpiece electrode customized for each subject. The peak inspiratory and tonic values of EMGgg and the corresponding esophageal pressure deflections (DP) during the last three occluded breaths of obstructive apneas during NREM sleep were analyzed. NA. 8 adult men with severe obstructive sleep apnea (OSA). NA. Paroxetine increased the peak inspiratory EMGgg (29.8+/-2.4 (SE) versus 24.4+/-2.7 % max, p
ISSN:0161-8105
1550-9109
DOI:10.1093/sleep/22.8.1087