Yttrium-90-labeled human macroaggregated albumin for internal radiotherapy: combined use with DTPA

The aim of this study was to investigate the possibility of yttrium-90-labeled human macroaggregated albumin ( 90Y-MAA) as an internal radiotherapeutic agent for whole-lung irradiation in combination with diethylenetriamine pentaacetic acid (DTPA). The influence of trisodium calcium DTPA (CaNa 3DTPA...

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Bibliographic Details
Published in:Nuclear medicine and biology 1999-10, Vol.26 (7), p.847-851
Main Authors: Watanabe, Naoyuki, Oriuchi, Noboru, Endo, Keigo, Inoue, Tomio, Tanada, Shuji, Murata, Hajime, Sasaki, Yasuhito
Format: Article
Language:English
Subjects:
90Y-MAA
Albumins - pharmacokinetics
Albumins - therapeutic use
Animals
Biological and medical sciences
CaNa 3DTPA
Chelating Agents - chemistry
Chelating Agents - pharmacokinetics
Chelating Agents - pharmacology
Contrast media. Radiopharmaceuticals
Female
Humans
Injections, Intraperitoneal
Injections, Intravenous
Lung - metabolism
Lung - radiation effects
Medical sciences
Mice
Mice, Inbred BALB C
Pentetic Acid - chemistry
Pentetic Acid - pharmacokinetics
Pentetic Acid - pharmacology
Pharmacology. Drug treatments
Radiopharmaceuticals - chemistry
Radiopharmaceuticals - pharmacokinetics
Radiopharmaceuticals - therapeutic use
Radiotherapy Dosage
Tissue Distribution
Whole-lung irradiation
Yttrium Radioisotopes - chemistry
Yttrium Radioisotopes - pharmacokinetics
Yttrium Radioisotopes - therapeutic use
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Summary:The aim of this study was to investigate the possibility of yttrium-90-labeled human macroaggregated albumin ( 90Y-MAA) as an internal radiotherapeutic agent for whole-lung irradiation in combination with diethylenetriamine pentaacetic acid (DTPA). The influence of trisodium calcium DTPA (CaNa 3DTPA) on the radioactivity of 90Y-MAA in serum was investigated in vitro. The effect of CaNa 3DTPA on the biodistribution of radioactivity in normal mice intraveneously injected with 90Y-MAA was examined. CaNa 3DTPA could deprive in vitro radioactivity of 90Y-MAA in 48-h incubation. Most of the radioactivity (>90% injected dose per lung) was observed at murine lung after injection of 90Y-MAA. Pulmonary radioactivity was cleared within 72 h postinjection, whereas the radioactivities in the bone, liver, kidneys, and spleen increased with a peak at 48 h. CaNa 3DTPA-treatment reduced the in vivo radioactivities in bone, liver, and kidneys without influence on the radioactivity of lung. In conclusion, combined use of CaNa 3DTPA enables 90Y-MAA to be used as a radiopharmaceutical for internal irradiation against whole lung.
ISSN:0969-8051
1872-9614
DOI:10.1016/S0969-8051(99)00064-5