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Preliminary screening of some traditional zulu medicinal plants for anti-inflammatory and anti-microbial activities
Aqueous and methanolic extracts from different parts of nine traditional Zulu medicinal plants, of the Vitaceae from KwaZulu-Natal, South Africa were evaluated for therapeutic potential as anti-inflammatory and anti-microbial agents. Of the twenty-nine crude extracts assayed for prostaglandin synthe...
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| Published in: | Journal of ethnopharmacology 1999-12, Vol.68 (1), p.267-274 |
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| cites | cdi_FETCH-LOGICAL-c480t-d846044c3f6d3e040c4b31bfada683cdba7502f95f0009ab8799b88bc985d0533 |
| container_end_page | 274 |
| container_issue | 1 |
| container_start_page | 267 |
| container_title | Journal of ethnopharmacology |
| container_volume | 68 |
| creator | Lin, J Opoku, A.R Geheeb-Keller, M Hutchings, A.D Terblanche, S.E K. Jäger, A van Staden, J |
| description | Aqueous and methanolic extracts from different parts of nine traditional Zulu medicinal plants, of the Vitaceae from KwaZulu-Natal, South Africa were evaluated for therapeutic potential as anti-inflammatory and anti-microbial agents. Of the twenty-nine crude extracts assayed for prostaglandin synthesis inhibitors, only five methanolic extracts of
Cyphostemma natalitium-root,
Rhoicissus digitata-leaf
, R. rhomboidea-root,
R. tomentosa-leaf/stem and
R. tridentata-root showed significant inhibition of cyclo-oxygenase (COX-1). The extracts of
R. digitata-leaf and of
R. rhomboidea-root exhibited the highest inhibition of prostaglandin synthesis with 53 and 56%, respectively. The results suggest that
Rhoicissus digitata leaves and of
Rhoicissus rhomboidea roots may have the potential to be used as anti-inflammatory agents. All the screened plant extracts showed some degrees of anti-microbial activity against Gram-positive and Gram-negative microorganisms. The methanolic extracts of
C. natalitium-stem and root,
R. rhomboidea-root, and
R. tomentosa-leaf/stem, showed different anti-microbial activities against almost all micro-organisms tested. Generally, these plant extracts inhibited the Gram-positive micro-organisms more than the Gram-negative ones. Several plant extracts inhibited the growth of
Candida albicans while only one plant extract showed inhibitory activity against
Saccharomyces cerevisiae. All the plant extracts which demonstrated good anti-inflammatory activities also showed better inhibitory activity against
Candida albicans. |
| doi_str_mv | 10.1016/S0378-8741(99)00130-0 |
| format | article |
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Cyphostemma natalitium-root,
Rhoicissus digitata-leaf
, R. rhomboidea-root,
R. tomentosa-leaf/stem and
R. tridentata-root showed significant inhibition of cyclo-oxygenase (COX-1). The extracts of
R. digitata-leaf and of
R. rhomboidea-root exhibited the highest inhibition of prostaglandin synthesis with 53 and 56%, respectively. The results suggest that
Rhoicissus digitata leaves and of
Rhoicissus rhomboidea roots may have the potential to be used as anti-inflammatory agents. All the screened plant extracts showed some degrees of anti-microbial activity against Gram-positive and Gram-negative microorganisms. The methanolic extracts of
C. natalitium-stem and root,
R. rhomboidea-root, and
R. tomentosa-leaf/stem, showed different anti-microbial activities against almost all micro-organisms tested. Generally, these plant extracts inhibited the Gram-positive micro-organisms more than the Gram-negative ones. Several plant extracts inhibited the growth of
Candida albicans while only one plant extract showed inhibitory activity against
Saccharomyces cerevisiae. All the plant extracts which demonstrated good anti-inflammatory activities also showed better inhibitory activity against
Candida albicans.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/S0378-8741(99)00130-0</identifier><identifier>PMID: 10624887</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Anti-Bacterial Agents ; Anti-Infective Agents - pharmacology ; Anti-inflammatory activity ; Anti-Inflammatory Agents - pharmacology ; Anti-microbial activity ; Biological and medical sciences ; Candida albicans - drug effects ; Cyclooxygenase Inhibitors - pharmacology ; Drug Evaluation, Preclinical - methods ; General pharmacology ; Gram-Negative Bacteria - drug effects ; Gram-Positive Bacteria - drug effects ; In Vitro Techniques ; Medical sciences ; Medicinal plants ; Medicine, Traditional ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plant Extracts - pharmacology ; Plants, Medicinal - chemistry ; Prostaglandins - biosynthesis ; Saccharomyces cerevisiae - drug effects ; Solubility ; South Africa ; traditional medicine ; Vitaceae ; Zulu</subject><ispartof>Journal of ethnopharmacology, 1999-12, Vol.68 (1), p.267-274</ispartof><rights>1999 Elsevier Science Ireland Ltd</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c480t-d846044c3f6d3e040c4b31bfada683cdba7502f95f0009ab8799b88bc985d0533</citedby><cites>FETCH-LOGICAL-c480t-d846044c3f6d3e040c4b31bfada683cdba7502f95f0009ab8799b88bc985d0533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1190076$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10624887$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, J</creatorcontrib><creatorcontrib>Opoku, A.R</creatorcontrib><creatorcontrib>Geheeb-Keller, M</creatorcontrib><creatorcontrib>Hutchings, A.D</creatorcontrib><creatorcontrib>Terblanche, S.E</creatorcontrib><creatorcontrib>K. Jäger, A</creatorcontrib><creatorcontrib>van Staden, J</creatorcontrib><title>Preliminary screening of some traditional zulu medicinal plants for anti-inflammatory and anti-microbial activities</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>Aqueous and methanolic extracts from different parts of nine traditional Zulu medicinal plants, of the Vitaceae from KwaZulu-Natal, South Africa were evaluated for therapeutic potential as anti-inflammatory and anti-microbial agents. Of the twenty-nine crude extracts assayed for prostaglandin synthesis inhibitors, only five methanolic extracts of
Cyphostemma natalitium-root,
Rhoicissus digitata-leaf
, R. rhomboidea-root,
R. tomentosa-leaf/stem and
R. tridentata-root showed significant inhibition of cyclo-oxygenase (COX-1). The extracts of
R. digitata-leaf and of
R. rhomboidea-root exhibited the highest inhibition of prostaglandin synthesis with 53 and 56%, respectively. The results suggest that
Rhoicissus digitata leaves and of
Rhoicissus rhomboidea roots may have the potential to be used as anti-inflammatory agents. All the screened plant extracts showed some degrees of anti-microbial activity against Gram-positive and Gram-negative microorganisms. The methanolic extracts of
C. natalitium-stem and root,
R. rhomboidea-root, and
R. tomentosa-leaf/stem, showed different anti-microbial activities against almost all micro-organisms tested. Generally, these plant extracts inhibited the Gram-positive micro-organisms more than the Gram-negative ones. Several plant extracts inhibited the growth of
Candida albicans while only one plant extract showed inhibitory activity against
Saccharomyces cerevisiae. All the plant extracts which demonstrated good anti-inflammatory activities also showed better inhibitory activity against
Candida albicans.</description><subject>Anti-Bacterial Agents</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Anti-inflammatory activity</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Anti-microbial activity</subject><subject>Biological and medical sciences</subject><subject>Candida albicans - drug effects</subject><subject>Cyclooxygenase Inhibitors - pharmacology</subject><subject>Drug Evaluation, Preclinical - methods</subject><subject>General pharmacology</subject><subject>Gram-Negative Bacteria - drug effects</subject><subject>Gram-Positive Bacteria - drug effects</subject><subject>In Vitro Techniques</subject><subject>Medical sciences</subject><subject>Medicinal plants</subject><subject>Medicine, Traditional</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Extracts - pharmacology</subject><subject>Plants, Medicinal - chemistry</subject><subject>Prostaglandins - biosynthesis</subject><subject>Saccharomyces cerevisiae - drug effects</subject><subject>Solubility</subject><subject>South Africa</subject><subject>traditional medicine</subject><subject>Vitaceae</subject><subject>Zulu</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNqFkV1r1jAUgIM43LvpT1B7IaIX1ZMmbZOrIWPqYLDB3HVI8zGOtMlr0g7015uuL-qdV0kOz_nIcwh5SeEDBdp9vAXWi1r0nL6T8j0AZVDDE7Kjom_qvu3ZU7L7gxyTk5y_A0BPOTwjxxS6hgvR70i-SW7ECYNOP6tsknMBw30VfZXj5Ko5aYszxqDH6tcyLtXkLBpcn_tRhzlXPqaqXLDG4Ec9TXqOpZIOdotOaFIcsPDazPhQarn8nBx5PWb34nCekrvPF9_Ov9ZX118uzz9d1YYLmGsreAecG-Y7yxxwMHxgdPDa6k4wYwfdt9B42fryMakH0Us5CDEYKVoLLWOn5O1Wd5_ij8XlWU2YjRvL4C4uWXWSyQZ4V8B2A8usOSfn1T7hVIwoCmq1rR5tq1WlklI92lZQ8l4dGixDEfNP1qa3AG8OgM5Gjz7pYDD_5agsK1n7v94wr6PS96kgd7fN2qSRjMuuKcTZRrji6wFdUtmgC6ZsIzkzKxvxP7P-BlXYp0c</recordid><startdate>19991215</startdate><enddate>19991215</enddate><creator>Lin, J</creator><creator>Opoku, A.R</creator><creator>Geheeb-Keller, M</creator><creator>Hutchings, A.D</creator><creator>Terblanche, S.E</creator><creator>K. Jäger, A</creator><creator>van Staden, J</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19991215</creationdate><title>Preliminary screening of some traditional zulu medicinal plants for anti-inflammatory and anti-microbial activities</title><author>Lin, J ; Opoku, A.R ; Geheeb-Keller, M ; Hutchings, A.D ; Terblanche, S.E ; K. Jäger, A ; van Staden, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c480t-d846044c3f6d3e040c4b31bfada683cdba7502f95f0009ab8799b88bc985d0533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Anti-Bacterial Agents</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>Anti-inflammatory activity</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Anti-microbial activity</topic><topic>Biological and medical sciences</topic><topic>Candida albicans - drug effects</topic><topic>Cyclooxygenase Inhibitors - pharmacology</topic><topic>Drug Evaluation, Preclinical - methods</topic><topic>General pharmacology</topic><topic>Gram-Negative Bacteria - drug effects</topic><topic>Gram-Positive Bacteria - drug effects</topic><topic>In Vitro Techniques</topic><topic>Medical sciences</topic><topic>Medicinal plants</topic><topic>Medicine, Traditional</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Extracts - pharmacology</topic><topic>Plants, Medicinal - chemistry</topic><topic>Prostaglandins - biosynthesis</topic><topic>Saccharomyces cerevisiae - drug effects</topic><topic>Solubility</topic><topic>South Africa</topic><topic>traditional medicine</topic><topic>Vitaceae</topic><topic>Zulu</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, J</creatorcontrib><creatorcontrib>Opoku, A.R</creatorcontrib><creatorcontrib>Geheeb-Keller, M</creatorcontrib><creatorcontrib>Hutchings, A.D</creatorcontrib><creatorcontrib>Terblanche, S.E</creatorcontrib><creatorcontrib>K. Jäger, A</creatorcontrib><creatorcontrib>van Staden, J</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, J</au><au>Opoku, A.R</au><au>Geheeb-Keller, M</au><au>Hutchings, A.D</au><au>Terblanche, S.E</au><au>K. Jäger, A</au><au>van Staden, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preliminary screening of some traditional zulu medicinal plants for anti-inflammatory and anti-microbial activities</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>1999-12-15</date><risdate>1999</risdate><volume>68</volume><issue>1</issue><spage>267</spage><epage>274</epage><pages>267-274</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>Aqueous and methanolic extracts from different parts of nine traditional Zulu medicinal plants, of the Vitaceae from KwaZulu-Natal, South Africa were evaluated for therapeutic potential as anti-inflammatory and anti-microbial agents. Of the twenty-nine crude extracts assayed for prostaglandin synthesis inhibitors, only five methanolic extracts of
Cyphostemma natalitium-root,
Rhoicissus digitata-leaf
, R. rhomboidea-root,
R. tomentosa-leaf/stem and
R. tridentata-root showed significant inhibition of cyclo-oxygenase (COX-1). The extracts of
R. digitata-leaf and of
R. rhomboidea-root exhibited the highest inhibition of prostaglandin synthesis with 53 and 56%, respectively. The results suggest that
Rhoicissus digitata leaves and of
Rhoicissus rhomboidea roots may have the potential to be used as anti-inflammatory agents. All the screened plant extracts showed some degrees of anti-microbial activity against Gram-positive and Gram-negative microorganisms. The methanolic extracts of
C. natalitium-stem and root,
R. rhomboidea-root, and
R. tomentosa-leaf/stem, showed different anti-microbial activities against almost all micro-organisms tested. Generally, these plant extracts inhibited the Gram-positive micro-organisms more than the Gram-negative ones. Several plant extracts inhibited the growth of
Candida albicans while only one plant extract showed inhibitory activity against
Saccharomyces cerevisiae. All the plant extracts which demonstrated good anti-inflammatory activities also showed better inhibitory activity against
Candida albicans.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>10624887</pmid><doi>10.1016/S0378-8741(99)00130-0</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of ethnopharmacology, 1999-12, Vol.68 (1), p.267-274 |
| issn | 0378-8741 1872-7573 |
| language | eng |
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| source | Elsevier |
| subjects | Anti-Bacterial Agents Anti-Infective Agents - pharmacology Anti-inflammatory activity Anti-Inflammatory Agents - pharmacology Anti-microbial activity Biological and medical sciences Candida albicans - drug effects Cyclooxygenase Inhibitors - pharmacology Drug Evaluation, Preclinical - methods General pharmacology Gram-Negative Bacteria - drug effects Gram-Positive Bacteria - drug effects In Vitro Techniques Medical sciences Medicinal plants Medicine, Traditional Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - pharmacology Plants, Medicinal - chemistry Prostaglandins - biosynthesis Saccharomyces cerevisiae - drug effects Solubility South Africa traditional medicine Vitaceae Zulu |
| title | Preliminary screening of some traditional zulu medicinal plants for anti-inflammatory and anti-microbial activities |
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