In Situ Gelling Hydrogels Incorporating Microparticles as Drug Delivery Carriers for Regenerative Medicine

Aqueous solutions of blends of biodegradable triblock copolymers, composed of poly(D,L-lactide-co-glycolide) (PLGA) and poly(ethylene glycol) (PEG) with varied D,L-lactide to glycolide ratios, displayed thermosensitivity and formed a gel at body temperature. The gel window of the blend solutions cou...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 2008-09, Vol.97 (9), p.3972-3980
Main Authors: Hou, Qingpu, Chau, David Y.S., Pratoomsoot, Chayanin, Tighe, Patrick J., Dua, Harminder S., Shakesheff, Kevin M., Rose, Felicity R.A.J.
Format: Article
Language:English
Subjects:
biodegradable polymers
Biological and medical sciences
Drug Carriers
drug delivery carriers
General pharmacology
Hydrogels
Medical sciences
Microscopy, Confocal
Microscopy, Electron, Scanning
Microspheres
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
polymer microparticles
Proteins - chemistry
Regenerative Medicine
Rheology
thermosensitive hydrogels
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Summary:Aqueous solutions of blends of biodegradable triblock copolymers, composed of poly(D,L-lactide-co-glycolide) (PLGA) and poly(ethylene glycol) (PEG) with varied D,L-lactide to glycolide ratios, displayed thermosensitivity and formed a gel at body temperature. The gel window of the blend solutions could be tuned by varying the blending ratio between the two components. Furthermore, the storage modulus of the resultant hydrogel from the copolymer blends at body temperature was higher than that of each individual component. Incorporation of poly(D,L-lactide) (PDLLA) microparticles (0.5–40% w/v) within the in situ gelling hydrogel did not change the sol–gel transition temperatures of the polymer solutions, while the mechanical strength of the resultant hydrogels was enhanced when the content of the microparticles was increased up to 30% and 40%. Incorporation of proteins into both the gel and microparticle components resulted in composites that controlled the kinetics of protein release. Protein within the gel phase was released over a 10-day period whilst protein in the microparticles was released over a period of months. This system can be used to deliver two drugs with differing release kinetics and could be used to orchestrate tissue regeneration responses over differing timescales.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.21310