Interleukin-6-174 Genotype, Periodontal Disease and Adverse Pregnancy Outcomes: A Pilot Study

This study was undertaken to investigate whether maternal periodontal disease and variant genotypes of IL-6 gene are associated with adverse pregnancy outcomes. A total of 145 pregnant women were recruited from St Mary’s Hospital, Manchester, UK. Bleeding on probing (BOP) and pocket depth indices we...

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Bibliographic Details
Published in:Journal of clinical immunology 2008-05, Vol.28 (3), p.237-243
Main Authors: Dashash, M., Nugent, J., Baker, P., Tansinda, D., Blinkhorn, F.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biomedical and Life Sciences
Biomedicine
European Continental Ancestry Group - genetics
Female
Fetal Growth Retardation - diagnosis
Fetal Growth Retardation - genetics
Fetal Growth Retardation - immunology
Genetic Predisposition to Disease
Genotype
Humans
Immunology
Infant, Newborn
Infectious Diseases
Interleukin-6 - genetics
Internal Medicine
Medical Microbiology
Periodontal Diseases - diagnosis
Periodontal Diseases - genetics
Periodontal Diseases - immunology
Periodontal Index
Pilot Projects
Polymorphism, Single Nucleotide - genetics
Pregnancy
Pregnancy Complications - diagnosis
Pregnancy Complications - genetics
Pregnancy Complications - immunology
Pregnancy Outcome - genetics
Prospective Studies
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Summary:This study was undertaken to investigate whether maternal periodontal disease and variant genotypes of IL-6 gene are associated with adverse pregnancy outcomes. A total of 145 pregnant women were recruited from St Mary’s Hospital, Manchester, UK. Bleeding on probing (BOP) and pocket depth indices were recorded on all teeth. Amplification refractory mutation system-polymerase chain reaction was used for −174 IL-6 genotyping. Birth weight was assessed using the individualized birth ratio (IBR) with intrauterine growth restriction (IUGR) defined as an IBR below the fifth percentile. The G/G genotype results in more BOP % sites in Caucasian( P  
ISSN:0271-9142
1573-2592
DOI:10.1007/s10875-007-9162-3