Proliferation marker Ki-S11 : a prognostic indicator for squamous cell carcinoma of the hypopharynx

As a potential prognostic factor, the proliferative activity of 131 squamous cell carcinomas (SCC) of the hypopharynx and 47 of their cervical lymph-node metastases was analyzed retrospectively by means of monoclonal antibody Ki-S11 immunostaining, which specifically detects the Ki-67 antigen on par...

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Bibliographic Details
Published in:Virchows Archiv : an international journal of pathology 1999-12, Vol.435 (6), p.590-595
Main Authors: KUROPKAT, C, RUDOLPH, P, FRAHM, S.-O, PARWARESCH, R, WERNER, J. A
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antibodies, Monoclonal
Biological and medical sciences
Carcinoma, Squamous Cell - diagnosis
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - mortality
Cell Division
Cell Nucleus - metabolism
Cell Nucleus - pathology
Cohort Studies
Female
Humans
Hypopharyngeal Neoplasms - diagnosis
Hypopharyngeal Neoplasms - metabolism
Hypopharyngeal Neoplasms - mortality
Immunoenzyme Techniques
Ki-67 Antigen - metabolism
Lymph Nodes - pathology
Lymphatic Metastasis
Male
Medical sciences
Middle Aged
Otorhinolaryngology. Stomatology
Prognosis
Survival Rate
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:As a potential prognostic factor, the proliferative activity of 131 squamous cell carcinomas (SCC) of the hypopharynx and 47 of their cervical lymph-node metastases was analyzed retrospectively by means of monoclonal antibody Ki-S11 immunostaining, which specifically detects the Ki-67 antigen on paraffin-embedded tissue. Median follow-up time was 37.6 months. Ki-S11 revealed distinctive patterns of proliferating cells related to the degree of differentiation. The proliferation fractions in the primaries and their lymph-node metastases did not differ significantly. Patients with high proliferating hypopharynx carcinomas (>45% labeled cells) had a significantly lower 5-year-survival rate (16%) than patients with low proliferating tumors, whose 5-year-survival rate was 30% (P=0.01). A statistically significant positive correlation was also observed between proliferative activity and lymph-node status (P=0.012). In conclusion, the proliferative activity as determined by means of Ki-S11 immunostaining is of prognostic value with respect to both survival and metastatic risk in SCC of the hypopharynx.
ISSN:0945-6317
1432-2307
DOI:10.1007/s004280050445