Apoptotic and effector pathways in autoimmunity

Programmed cell death is an important anti-autoimmune mechanism used to delete autoreactive lymphocytes and to limit the spread both of viral infections and of tissue damage caused by immune responses. However, in autoimmune diseases, activation of programmed cell death by effector mechanisms that a...

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Bibliographic Details
Published in:Current Opinion in Immunology 1999-12, Vol.11 (6), p.684-688
Main Author: Chervonsky, Alexander V
Format: Article
Language:English
Subjects:
Animals
Antigen-presenting cell
Apoptosis
Autoimmune Diseases - immunology
Autoimmune Diseases - pathology
Autoimmunity
Fas
Humans
Programmed cell-death
TNF
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Summary:Programmed cell death is an important anti-autoimmune mechanism used to delete autoreactive lymphocytes and to limit the spread both of viral infections and of tissue damage caused by immune responses. However, in autoimmune diseases, activation of programmed cell death by effector mechanisms that are similar to the normal immune response leads to augmented destruction of the targeted tissues.
ISSN:0952-7915
1879-0372
DOI:10.1016/S0952-7915(99)00037-0