11C-Acetate PET in the Evaluation of Brain Glioma: Comparison with 11C-Methionine and 18F-FDG-PET

Purpose The aim of the study is to retrospectively investigate the usefulness of 11 C-acetate (ACE)-positron emission tomography (PET) for evaluation of brain glioma, in comparison with 11 C-methionine (MET) and 2-deoxy-2- 18 F-fluoro- d -glucose (FDG). Procedures Fifteen patients with brain glioma...

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Bibliographic Details
Published in:Molecular imaging and biology 2008-09, Vol.10 (5), p.281-287
Main Authors: Yamamoto, Y., Nishiyama, Y., Kimura, N., Kameyama, R., Kawai, N., Hatakeyama, T., Kaji, M., Ohkawa, M.
Format: Article
Language:English
Subjects:
Acetates
Adult
Aged
Aged, 80 and over
Brain Neoplasms - diagnosis
Carbon Isotopes
Female
Fluorodeoxyglucose F18
Glioma - diagnosis
Humans
Imaging
Magnetic Resonance Imaging
Male
Medicine
Medicine & Public Health
Methionine
Middle Aged
Positron-Emission Tomography - methods
Radiology
Research Article
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Summary:Purpose The aim of the study is to retrospectively investigate the usefulness of 11 C-acetate (ACE)-positron emission tomography (PET) for evaluation of brain glioma, in comparison with 11 C-methionine (MET) and 2-deoxy-2- 18 F-fluoro- d -glucose (FDG). Procedures Fifteen patients with brain glioma referred to initial diagnosis were examined with ACE, MET, and FDG-PET. Five patients had low-grade gliomas (grade II), three had anaplastic astrocytomas (grade III), and seven had glioblastomas (grade IV). PET results were evaluated by visual and semiquantitative analysis. For semiquantitative analysis, the standardized uptake value (SUV) and tumor to contralateral normal gray matter ( T / N ) ratio were calculated. The sensitivity for detection of high-grade gliomas was calculated using visual analysis. Results Sensitivities of ACE, MET, and FDG were 90%, 100%, and 40%, respectively. ACE and MET T / N ratios were significantly higher than that of FDG. ACE and FDG SUV in high-grade gliomas were significantly higher than that in low-grade gliomas. No significant differences were observed using MET. Conclusions ACE PET is a potentially useful radiotracer for detecting brain gliomas and differentiating high-grade gliomas.
ISSN:1536-1632
1860-2002
DOI:10.1007/s11307-008-0152-5